Disease table of HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO OMIM ID: 609423

Gene-disease associations table

Gene	Associated with HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CCL2	ClinVar, OMIM	HGNC link	17q12	3	609423, 607948, 182940
CCL11	ClinVar, OMIM	HGNC link	17q12	2	600807, 609423
IL4R	OMIM	HGNC link	16p12.1	2	147050, 609423
CX3CR1	OMIM	HGNC link	3p22.2	3	607339, PS603075, 609423
CCL3	OMIM	HGNC link	17q12	1	609423
HLA-C	OMIM	HGNC link	6p21.33	2	609423, PS177900
CXCR1	OMIM	HGNC link	2q35	1	609423
CD209	ClinVar, OMIM	HGNC link	19p13.2	3	609423, 607948, 614371
CCR2	ClinVar, OMIM	HGNC link	3p21.31	1	609423
CCR5	ClinVar, OMIM	HGNC link	3p21.31	4	612522, 609423, 610379, 609532
KIR3DL1	OMIM	HGNC link	19q13.42	1	609423
IFNG	OMIM	HGNC link	12q15	5	609135, PS191100, 609532, 607948, 609423
IL10	ClinVar, OMIM	HGNC link	1q32.1	3	180300, 614395, 609423
CXCL12	ClinVar, OMIM	HGNC link	10q11.21	1	609423
CCL3L1	OMIM	HGNC link	17-	1	609423
TLR3	ClinVar, OMIM	HGNC link	4q35.1	2	PS610551, 609423

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 165	2	CCR5, CCR2
Group 753	2	CCL2, CCL11

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
17q12	3	CCL2, CCL11, CCL3
3p21.31	2	CCR5, CCR2

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
17q12	3	CCL2, CCL11, CCL3
3p21	2	CCR5, CCR2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q1	3	CCL2, CCL11, CCL3
3p2	3	CCR5, CCR2, CX3CR1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3p	3	CCR5, CCR2, CX3CR1
17q	3	CCL2, CCL11, CCL3

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
17	3	CCL2, CCL11, CCL3
19	2	CD209, KIR3DL1
3	3	CCR5, CCR2, CX3CR1

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
NFATC2	NO	11	EGR3, MDM2, IL4, FOXP3, CD3G, IL10, IFNG, BACE1, CCNA2, TERT, ENPP2	2	IL10, IFNG
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	3	KIR3DL1, CCR5, IFNG
TBX21	NO	14	IL12RB2, SPP1, GATA3, IL4, CXCR3, CHST4, IFNG, IL23R, NELFCD, CCR4, IL10, IL13, PTGDR2, FUT7	2	IL10, IFNG
REL	NO	22	F3, TNFAIP3, SELE, BCL2A1, EPHB2, IL12B, IL2RA, CCL5, KLK3, IL1B, CDKN1A, CRP, IL10, BIRC3, IER3, ICAM1, IL2, CD40LG, CCL2, IL6, CSRP1, SOD2	2	IL10, CCL2
MSC	NO	11	CDC25A, IL2RA, CDC6, LTA, FOXP3, IL10, IFNG, MMP2, MCM7, DKK1, CTLA4	2	IL10, IFNG
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	3	CCL11, IL10, IFNG
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	4	CCL3, TLR3, IFNG, CCL2
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	IFNG, CCL2
GATA3	NO	33	IL12RB2, KLK1, CHST4, IFNG, EPO, ERVW-1, TEK, MUC1, CD40LG, HSD17B1, TRA, ERG, ESR1, FUT7, ZEB1, CDH3, CDX2, FOXC1, FOXC2, PAEP, IL10, CDH1, MMP1, CD8A, DLC1, CXCL1, GATA3, IL4, IL5, EPOR, CD8B, STAT4, MYCN	2	IL10, IFNG
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	9	CCL11, TLR3, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	9	CCL11, TLR3, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
MYCN	NO	44	MCM8, MCM7, HDAC2, TP53, BIRC5, IFNG, HLA-F, MCM3, LRRN3, BMI1, SKP2, MDM2, ABCB1, MCM2, DDB1, NES, CD44, HLA-C, HLA-G, CDKN1A, TP53INP1, HLA-B, NGFR, HLA-A, CIITA, MCM6, CTSD, ABCC1, LXN, DKK3, BAX, CDK6, HLA-E, NDRG1, TH, EFNB3, ID2, MCM5, MCM10, MYCL, TERT, NTRK1, MCM4, CDKN1B	2	IFNG, HLA-C
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	IL10, CCL2
PARP1	NO	25	FN1, SNAI1, IFNAR1, IFNG, VIM, SERPINE1, TERF2, TCF4, THBD, FOXO1, E2F1, CDKN1A, SMARCB1, CDH1, SH3BP2, FBN1, IL10, RELA, NFKB1, CXCL1, BRCA2, BCL2, HTR1A, JUN, SERPINF1	2	IL10, IFNG
CREB1	NO	90	NDC80, NRF1, IFNG, NR2F1, CYP19A1, CASP8, LDHA, SMAD6, SLC19A1, GSK3A, IL10, PSEN1, PPP2R2B, JUN, HPGD, IL2, GABPA, MC2R, CRTC1, AR, FLT1, SLC39A1, BDKRB2, NPY, PTGS2, MSMB, CFTR, HMOX1, MITF, AQP3, MUC5AC, STMN1, TRH, PCSK1, MMP2, CYP17A1, NOLC1, PRL, NMNAT2, TLR9, NTS, PLAT, FOS, BCL2L11, MUC4, GSK3B, CYP11B1, PPM1D, CCK, ETV3, PTGES, UXT, HLA-DOB, CGA, XPC, ACACA, SLC22A8, TH, VIP, BDKRB1, CYP11B2, POLD2, LAPTM4B, SOX9, PLAU, SNAI1, PPP2CA, SNAI2, SPRY2, HLA-DQB1, CCL5, CXCR4, ADRA1A, NR5A2, ERBB2, GRPR, BDNF, NR4A3, IL5RA, SLC20A1, RRM2B, LYL1, BCL2, CD4, NR2F6, NF1, IL6, CYP11A1, ODC1, FOXA1	2	IL10, IFNG
IRF3	NO	16	IRF5, IFNB1, TLR3, CCL5, TNPO1, IFNA1, IFNL1, IRF7, TANK, ABCC2, CXCL10, PURA, MAVS, SOCS2, CCL2, TLR4	2	TLR3, CCL2
IRF1	NO	51	EIF2AK2, IFNA13, PSMB10, IL12A, NCF2, CEACAM1, MMP9, MYB, PSMB9, IL12B, TAP2, CCNE1, CCL5, SOCS2, VCAM1, TNFSF10, SOCS1, MAPK14, IFNA1, HLA-G, CASP7, CDKN1A, IFNB1, CCNB1, FOXP3, OGN, PIGR, IL10, TAP1, TP53, TRIM22, HLA-A, DDX58, CD40, ERAP2, IL27, CDK1, E2F1, TAPBP, CYBB, CDK2, BCL2, CDK4, CXCL10, SLPI, IRF2, DST, IFIT3, CIITA, IFNG, FASLG	2	IL10, IFNG
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	3	KIR3DL1, CCL3, TLR3
NR1I2	NO	26	BCL2L1, CYP2C9, FOSL1, PTAFR, TNFRSF12A, THRSP, ABCB1, THBS1, CYP2B6, CYP3A4, CYP2C8, NOD2, HP, IL10, CYP4F12, NOD1, UGT1A1, RELA, NFKB1, RXRA, FGF19, BCL2, CORO1C, CCL2, RAB3A, KLF6	2	IL10, CCL2
STAT5A	NO	10	BCL2L1, CEL, BCL6, SUMO1, CCND1, IFNG, IL10, ESR1, CCND2, CDKN2B	2	IL10, IFNG

regulated gene	associated to this disease	# TFs	TFs
CCL2	YES	17	SP1, XBP1, NFAT5, NFKB1, PREB, HEY1, HDAC2, NFIC, NR1I2, ATF4, JUN, IRF3, RELA, APEX1, MAML1, REL, STAT1
CCL11	YES	4	STAT6, STAT3, NFKB1, RELA
CCL3	YES	5	RUNX1, E2F1, NFKB1, STAT1, RELA
HLA-C	YES	4	CIITA, MYC, HIVEP2, MYCN
CXCR1	YES	1	SPI1
CCR2	YES	3	AR, NFKB1, RELA
CCR5	YES	5	NR3C2, YY1, NFKB1, KLF2, RELA
KIR3DL1	YES	2	YY1, E2F1
IFNG	YES	29	BCL6, TFAP4, NFATC2, TBX21, EGR1, NFKB1, CREB1, STAT5A, NFATC1, JUN, GATA1, ATF2, RELA, PARP1, GATA3, EP300, STAT1, STAT3, PROX1, RFX5, EOMES, YY1, NFIL3, STAT5B, MSC, MYCN, STAT4, IRF1, USF1
IL10	YES	23	HDAC4, NFATC2, FLI1, PGR, TBX21, REL, SP1, IRF4, CREB1, NR1I2, STAT5A, VDR, HDAC11, ATF1, RELA, PARP1, NFKB1, STAT3, GATA3, CEBPA, IRF1, MSC, CEBPB
CXCL12	YES	6	ESR1, SNAI2, HIF1A, RELA, NFKB1, FOXF2
TLR3	YES	6	IRF8, IRF3, RELA, E2F1, NFKB1, STAT1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CCL2	CCL11	No	1	CCR3
CCL2	CXCL12	No	1	VCAN
CCL2	CCL3L1	No	1	CCR3
CCL11	CCL3L1	No	1	CCR3
IL4R	CCR5	No	1	JAK2
IL4R	IFNG	No	1	STAT6
CCL3	CCR5	Yes	1	CCL3
CCL3	CCL3L1	No	1	CCR5
HLA-C	KIR3DL1	No	3	KIR2DL2, KIR2DS2, ENV
CCR5	CXCL12	No	1	CXCR4
CCR5	CCL3L1	Yes	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
CCL2	CCL11	Yes	binding	28	CXCR1, CXCR6, OSM, CCL22, CCR10, CCL4, CCR7, CCL7, CCBP2, CCL5, CCR6, CCR5, CCL3, PPARA, CCR1, CXCR3, CCR4, CCR3, SRC, CXCR5, XCR1, CX3CR1, IL4, CCR2, CXCR2, CCL17, CCR8, CCR9
CCL2	IL4R	No	-	10	CSF2, OSM, IL4, IL23A, TYK2, IL10, IL6, JAK2, CTF1, MAPK14
CCL2	CX3CR1	Yes	activation, binding	9	CCL22, CCL7, CCL11, CCL5, CXCL2, CCL17, JAK2, CCL4, CCL3
CCL2	CCL3	Yes	binding	30	TYK2, CXCR6, CCL22, CXCR1, JAK2, IL12RB1, CCL11, CCL4, CCL17, FOS, CCR7, CCL7, CCBP2, CCL5, CCR6, CCR5, CCR1, CXCR3, CCR10, CCR4, CCR3, CXCR5, NFKB1, XCR1, CX3CR1, CCR2, CXCR2, JUN, CCR8, CCR9
CCL2	CXCR1	Yes	activation, binding	23	CCR10, CXCR6, CXCR2, JAK2, CCL11, CCL4, CXCR5, CCL7, CCL5, CCR6, CCR1, CCL3, CXCR3, CXCL2, CCR4, CCR3, CCR7, CCR5, CCR2, CCL22, CCL17, CCR8, CCR9
CCL2	CD209	No	-	4	SRC, TGFB1, IL4, IL10
CCL2	CCR2	Yes	activation, binding	25	CCR10, CXCR6, CXCR2, CXCR1, JAK2, CCL11, CCL4, ICAM1, CXCR5, CCL7, CCL5, CCR6, CCR1, CCL3, CXCR3, CXCL2, CCR4, CCR3, CCR7, CCR5, CCL22, CCL17, CCR8, PPARG, CCR9
CCL2	CCR5	Yes	activation, binding	28	TYK2, CXCR6, CCL22, CXCR1, JAK2, IL12RB1, CCL11, CCL4, CCL17, CCR7, CCL7, CCL5, CCR6, CCL3, CXCR3, CCR10, CXCL2, CCR4, CCR3, IL10, CXCR5, CCR1, IL4, CCR2, CXCR2, JUN, CCR8, CCR9
CCL2	IFNG	No	-	8	TYK2, IL23A, JUN, JAK2, IL23R, IL12RB1, TGFB1, FOS
CCL2	IL10	Yes	activation, binding	14	ICAM1, CSF2, HMOX1, IL4, IL6, MMP2, IL23R, JUN, MMP9, IL12RB1, MAPK14, FOS, VEGFA, CCR5
CCL2	CXCL12	No	-	34	CXCR1, CXCR6, CCR10, JAK2, MMP9, MMP2, CCL11, FGF2, ICAM1, CCR7, CCL5, CCR6, CCR5, PPARA, CCR1, CXCR3, CXCL2, CCR4, CCR3, TP53, SRC, CXCR5, XCR1, CX3CR1, CCR2, CXCR2, MMP1, CCR8, PTH, IL6, HMOX1, NAMPT, VEGFA, CCR9
CCL2	CCL3L1	No	-	3	CCR3, CCR5, CCR1
CCL11	IL4R	No	-	5	IL9, IL13, STAT6, OSM, IL4
CCL11	CX3CR1	Yes	activation	11	CCL7, CCL5, CCL22, CXCL12, CCL17, CCL2, ARRB1, CXCL10, ADRBK1, CCL4, CCL3
CCL11	CCL3	Yes	binding	24	CCR10, CXCR6, CCL22, CXCR1, CCR8, CCL4, CCR7, CCL7, CCBP2, CCL5, CCR6, CCR5, CCR1, CXCR3, CCR4, CCR3, CXCR5, XCR1, CX3CR1, CCR2, CXCR2, CCL17, CCL2, CCR9
CCL11	CXCR1	Yes	activation	31	CCR10, CXCR6, GNG2, HCK, CCL22, AGT, CCR8, CCL4, CXCR5, CCL7, CCL5, CXCL12, CCR6, ARRB1, FGR, ADRBK1, CCL3, GNB1, CCR1, CXCL10, CXCR3, CCR4, CCR3, DNM1, CCR7, CCR5, CCR2, CXCR2, CCL17, CCL2, CCR9
CCL11	CD209	No	-	2	SRC, IL4
CCL11	CCR2	Yes	activation, binding	28	CXCR1, CXCR6, GNG2, CCL22, CCR10, AGT, CCR8, CCL4, CXCR5, CCL7, CCL5, CXCL12, CCR6, ARRB1, CCR1, ADRBK1, CCL3, GNB1, CXCL10, CXCR3, CCR4, CCR3, CCR7, CCR5, CXCR2, CCL17, CCL2, CCR9
CCL11	CCR5	Yes	activation, binding	41	CXCR1, CXCR6, GNG2, CCL22, CCR10, AGT, CCL2, GNAQ, CCL4, CXCR5, CCL7, CHRM1, CCL5, CXCL12, CCR6, ARRB1, EDN1, ADRBK1, CCL3, F2, GNB1, ADRB2, CXCL10, CXCR3, HRAS, CCR4, CCR3, GNGT1, PTGER1, CCR7, CCR1, STAT3, IL4, CCR2, CXCR2, CCL17, CCR8, ADRA1B, GNAS, P2RY2, CCR9
CCL11	IFNG	No	-	3	MAPK1, STAT3, STAT6
CCL11	IL10	No	-	6	STAT3, IL4, CXCL10, CCL2, STAT6, CCR5
CCL11	CXCL12	Yes	binding	58	PRKACG, CXCR1, CXCR6, AP2M1, GNG2, HCK, MAPK1, CCR10, AP2A1, AGT, CXCL10, GNAQ, EZR, CXCR5, CHRM1, CCL5, PRKAR2A, MAP2K2, EDN1, CFTR, CCR6, ARRB1, XCR1, RAF1, FGR, TUB, PPARA, F2, GNB1, CCR1, ADRB2, ADRBK1, CXCR3, HRAS, PRKAR2B, CX3CR1, CCR4, PRKAR1A, SLC9A3R1, GNGT1, DNM1, PTGER1, SRC, CCR7, PLCB1, P2RY2, CCR5, STAT3, CCR2, CXCR2, CCR3, CCR8, ADRA1B, GNAS, PRKAR1B, PRKACB, MAP2K1, CCR9
CCL11	CCL3L1	No	-	3	CCR3, CCR5, CCR1
IL4R	CX3CR1	No	-	1	JAK2
IL4R	CCL3	No	-	5	TYK2, SOCS1, IL12A, IFNA1, JAK2
IL4R	CXCR1	No	-	1	JAK2
IL4R	CD209	No	-	2	IL4, IL10
IL4R	CCR2	No	-	2	IL2, JAK2
IL4R	CCR5	No	-	5	TYK2, JAK2, IL12A, IL4, IL10
IL4R	IFNG	Yes	activation, binding	25	TYK2, IL12A, IFNA5, JAK2, JAK1, IL13RA1, STAT6, IFNA14, SOCS1, PIK3CA, SOCS3, IFNA10, IFNA7, IFNA6, IFNA21, STAT5A, IFNA2, IFNA4, IL2, PIK3R1, IL23A, IFNA17, IFNA8, IFNA16, CBL
IL4R	IL10	Yes	activation, binding	15	CSF2, GATA3, IL4, IRF4, IL15, SOCS3, UBC, IL13RA1, IL6, JAK1, IFNA2, IL2, IL19, STAT6, MAPK14
IL4R	CXCL12	No	-	6	STAT5A, IL3, CSF3, JAK2, IL6, STAT5B
CX3CR1	CCL3	Yes	activation, binding	8	CCL7, CCL11, CCL5, CCL22, CCL17, CCL2, JAK2, CCL4
CX3CR1	CXCR1	No	-	53	PF4, CCL16, CCL11, CCL1, CCL17, GRK1, JAK2, CCL4L1, CCL27, XCL1, CXCL10, CCL4, ADRBK2, CCL18, GNAI3, CCL7, CCL19, CCL21, CCL5, ARRB2, GRK6, CXCL5, CXCL9, ARRB1, ADRBK1, CXCL6, CCL3, CCL13, CXCL13, PPBP, CXCL14, CCL25, GRK4, CCL15-CCL14, GRK5, CXCL2, CXCL1, CCL14, GRK7, IL8, XCL2, CCL20, CXCL16, CXCL11, CX3CL1, CCL22, PF4V1, CCL2, CCL28, CCL8, CXCL3, CXCL12, CCL23
CX3CR1	CCR2	No	-	53	PF4, CCL16, CCL11, CCL1, CCL17, GRK1, JAK2, CCL4L1, CCL27, XCL1, CXCL10, CCL4, ADRBK2, CCL18, GNAI3, CCL7, CCL19, CCL21, CCL5, ARRB2, GRK6, CXCL5, CXCL9, ARRB1, ADRBK1, CXCL6, CCL3, CCL13, CXCL13, PPBP, CXCL14, CCL25, GRK4, CCL15-CCL14, GRK5, CXCL2, CXCL1, CCL14, GRK7, IL8, XCL2, CCL20, CXCL16, CXCL11, CX3CL1, CCL22, PF4V1, CCL2, CCL28, CCL8, CXCL3, CXCL12, CCL23
CX3CR1	CCR5	No	-	53	PF4, CCL16, CCL11, CCL1, CCL17, GRK1, JAK2, CCL4L1, CCL27, XCL1, CXCL10, CCL4, ADRBK2, CCL18, GNAI3, CCL7, CCL19, CCL21, CCL5, ARRB2, GRK6, CXCL5, CXCL9, ARRB1, ADRBK1, CXCL6, CCL3, CCL13, CXCL13, PPBP, CXCL14, CCL25, GRK4, CCL15-CCL14, GRK5, CXCL2, CXCL1, CCL14, GRK7, IL8, XCL2, CCL20, CXCL16, CXCL11, CX3CL1, CCL22, PF4V1, CCL2, CCL28, CCL8, CXCL3, CXCL12, CCL23
CX3CR1	IFNG	No	-	2	JAK2, CXCL11
CX3CR1	IL10	No	-	3	IL8, CXCL10, CCL2
CX3CR1	CXCL12	Yes	activation, binding	29	PF4, CCL16, CCL11, CXCL13, JAK2, CXCL10, GNAI3, CCL19, CCL5, ARRB2, GRK6, CXCL9, ARRB1, ADRBK1, CXCL6, PPBP, CXCL14, CCL25, CCL21, CXCL5, CXCL2, CXCL1, IL8, CCL20, CXCL16, CXCL11, CCL27, CCL28, CXCL3
CCL3	CXCR1	Yes	activation, binding	22	CCR10, CXCR6, CXCR2, JAK2, CCR8, CCL11, CCL4, CCR7, CCL7, CCL5, CCR6, CCR1, CXCR3, CCR4, CCR3, CXCR5, CCR5, CCR2, CCL22, CCL17, CCL2, CCR9
CCL3	CCR2	Yes	activation, binding	22	CCR10, CXCR6, CXCR2, CXCR1, JAK2, CCR8, CCL11, CCL4, CCR7, CCL7, CCL5, CCR6, CCR1, CXCR3, CCR4, CCR3, CXCR5, CCR5, CCL22, CCL17, CCL2, CCR9
CCL3	CCR5	Yes	activation, binding	27	IL12RB2, TYK2, CXCR6, CCL22, IL12A, CXCR1, JAK2, IL12RB1, CCR8, CCL11, CCL4, CCL17, CXCR5, CCL7, CCL5, CCR6, CXCR3, CCR10, CCR4, CCR3, CCR7, CCR1, CCR2, CXCR2, JUN, CCL2, CCR9
CCL3	IFNG	No	-	9	IL12RB2, TYK2, IL12A, IL12RB1, JAK2, SOCS1, JUN, RELA, FOS
CCL3	IL10	No	-	6	IL12RB2, JUN, CCL2, IL12RB1, FOS, CCR5
CCL3	CXCL12	No	-	21	CX3CR1, CXCR1, XCR1, CCR9, CCL5, CCR10, CXCR2, CCR2, CXCR6, CCR5, CCR6, CCR4, JAK2, CCR3, TNFSF11, CXCR3, CCR8, CCR7, CXCR5, CCR1, CCL11
CCL3	CCL3L1	No	-	3	CCR3, CCR5, CCR1
CXCR1	CCR2	Yes	reaction, binding	187	PF4, CCL16, P2RY14, CCL1, GRK1, GPR17, ADRA2B, AGT, HRH4, XCL1, CCL21, CCL4, P2RY4, GRM6, C3AR1, OPRM1, CCL19, SSTR5, HCAR2, CXCL12, NPB, FPR3, CXCL6, CCL25, CNR2, SAA1, CXCL14, NMUR1, GPR55, GRK4, CXCL1, GPER, OXGR1, GRM8, SSTR2, CCR5, ADORA3, CCL22, CCL2, CCL28, NPY5R, CXCL3, PTGDR2, GAL, CCL23, TAS2R1, CCL11, S1PR4, JAK2, SSTR3, BDKRB2, NPY, ADRBK2, NMUR2, CCL7, CCL14, HRH3, OPRK1, P2RY13, HCAR3, CCL13, OPRL1, ADORA1, GPR18, TAS2R16, PNOC, HTR1E, ADRA2A, XCL2, CCR1, CCL20, NPBWR1, CXCL11, CCR6, CXCR2, GRK7, PENK, GNAT3, CCR9, CHRM2, PTGER3, ANXA1, MCHR1, P2RY12, PDYN, GNG2, CXCL13, DRD3, FPR2, SUCNR1, TAS2R42, CXCR6, MTNR1B, LPAR3, CXCR5, APP, TAS2R4, TAS2R41, RXFP3, TAS2R39, CXCL9, DRD2, POMC, CCL18, GALR2, NPY1R, PPBP, MCHR2, CXCR3, HTR5A, PPY, GRK5, CXCL2, CXCL16, HCAR1, CCR3, IL8, GRM3, HTR1F, CCR7, C5AR1, TAS2R5, HTR1A, TAS2R40, CX3CL1, CHRM4, TAS2R43, CXCL10, GNAI3, CCL8, OPRD1, BDKRB1, HTR1B, SST, APLNR, HEBP1, SSTR4, CCR10, KNG1, APLN, TAS2R60, RXFP4, LPAR5, PMCH, CCL4L1, CCR8, CXCR7, MTNR1A, GNAI1, CASR, S1PR1, CCL5, ARRB2, GRK6, CCL15-CCL14, ARRB1, ADRBK1, CCL3, S1PR5, GNB1, ADRA2C, LPAR2, CNR1, CXCL5, GALR1, OXER1, PF4V1, SSTR1, NMU, CCR4, GRM4, HTR1D, LPAR1, TAS2R3, PYY, S1PR3, GRM7, NMS, MTRNR2L2, GALR3, CCL17, CCL27, NPBWR2, GRM2, DRD4, NPY2R, NPW
CXCR1	CCR5	Yes	reaction, binding	187	PF4, CCL16, P2RY14, CCL1, GRK1, GPR17, ADRA2B, AGT, HRH4, XCL1, CCL4, P2RY4, GRM6, C3AR1, TAS2R16, CCL19, SSTR5, HCAR2, CXCL12, NPB, FPR3, CXCL6, CCL25, CNR2, SAA1, CXCL14, NMUR1, GPR55, GRK4, ADORA3, GPER, OXGR1, FPR2, SSTR2, CXCL1, CCR2, CCL22, CCL2, CCL28, NPY5R, CXCL3, PTGDR2, GAL, CCL23, TAS2R1, CCL11, S1PR4, JAK2, SSTR3, BDKRB2, NPY, ADRBK2, NMUR2, GALR1, CNR1, HRH3, OPRM1, OPRK1, P2RY13, HCAR3, CCL13, OPRL1, ADORA1, GPR18, PNOC, CCL14, ADRA2A, XCL2, CCR1, CCL20, HTR1E, NPBWR1, CXCL11, CXCR2, GRK7, PENK, GNAT3, CCR9, CHRM2, PTGER3, ANXA1, MCHR1, P2RY12, PDYN, GNG2, CXCL13, DRD3, GRM8, SUCNR1, TAS2R42, CXCR6, MTNR1B, LPAR3, CXCR5, APP, TAS2R4, TAS2R41, RXFP3, TAS2R39, CCR6, DRD2, CXCL9, CCL18, GALR2, NPY1R, PPBP, MCHR2, CXCR3, HTR5A, PPY, GRK5, CXCL2, CXCL16, HCAR1, CCR3, IL8, GRM3, HTR1F, CCR7, C5AR1, TAS2R5, HTR1A, TAS2R40, CX3CL1, CHRM4, TAS2R43, CXCL10, GNAI3, CCL8, OPRD1, BDKRB1, HTR1B, SST, POMC, APLNR, HEBP1, SSTR4, CCR10, KNG1, APLN, TAS2R60, RXFP4, LPAR5, PMCH, CCL4L1, CCR8, CXCR7, MTNR1A, GNAI1, CASR, S1PR1, CCL5, ARRB2, GRK6, CCL15-CCL14, ARRB1, ADRBK1, CCL3, S1PR5, GNB1, ADRA2C, LPAR2, CCL21, CXCL5, CCL7, OXER1, PF4V1, SSTR1, NMU, CCR4, GRM4, HTR1D, LPAR1, TAS2R3, PYY, S1PR3, GRM7, NMS, MTRNR2L2, GALR3, CCL17, CCL27, NPBWR2, GRM2, DRD4, NPY2R, NPW
CXCR1	IFNG	No	-	2	JAK2, CXCL11
CXCR1	IL10	No	-	4	IL8, CCR5, CXCL10, CCL2
CXCR1	CXCL12	Yes	activation, binding	167	PF4, CCL16, P2RY14, GPR17, ADRA2B, AGT, HRH4, TAS2R4, P2RY4, GRM6, C3AR1, TAS2R16, CCL19, SSTR5, HCAR2, ANXA1, NPB, FPR3, CXCL6, CCL25, CNR2, SAA1, NMUR1, GPR55, CXCL1, GPER, OXGR1, HCAR1, FPR2, SSTR2, CCR5, ADORA3, CCR2, TAS2R43, CCL28, NPY5R, CXCL3, PTGDR2, GAL, TAS2R1, CCL11, S1PR4, JAK2, SSTR3, BDKRB2, KNG1, NMUR2, GALR1, CCL21, HRH3, OPRM1, OPRK1, P2RY13, HCAR3, OPRL1, ADORA1, GPR18, PNOC, HTR1E, ADRA2A, CXCR5, CCR1, CCL20, NPBWR1, CXCL11, CCR6, CXCR2, CXCL14, GNAT3, GRM7, CHRM2, PTGER3, MCHR1, P2RY12, PDYN, GNG2, CXCL13, CCR10, GRM8, SUCNR1, TAS2R42, CXCR6, MTNR1B, LPAR3, APP, PENK, TAS2R41, CCR9, RXFP3, TAS2R39, CXCL9, DRD2, TAS2R60, POMC, CASR, GALR2, NPY1R, PPBP, MCHR2, CXCR3, HTR5A, PPY, S1PR5, CXCL2, CXCL16, DNM1, CCR3, IL8, GRM3, HTR1F, CCR7, C5AR1, FGR, TAS2R5, HTR1A, TAS2R40, CHRM4, CXCL10, GNAI3, OPRD1, BDKRB1, HTR1B, SST, APLNR, HEBP1, SSTR4, DRD3, APLN, HCK, LPAR5, PMCH, CCR8, CXCR7, MTNR1A, GNAI1, NPY, S1PR1, CCL5, ARRB2, GRK6, ARRB1, ADRBK1, GNB1, ADRA2C, LPAR2, CNR1, CXCL5, OXER1, SSTR1, NMU, CCR4, GRM4, HTR1D, LPAR1, TAS2R3, PYY, S1PR3, NMS, MTRNR2L2, GALR3, RXFP4, CCL27, NPBWR2, GRM2, DRD4, NPY2R, NPW
CXCR1	CCL3L1	No	-	3	CCR3, CCR5, CCR1
CD209	CCR5	No	-	3	ITIH4, IL4, IL10
CD209	IFNG	No	-	1	TGFB1
CD209	IL10	Yes	activation, binding	2	ITIH4, IL4
CD209	CXCL12	No	-	2	SRC, LCK
CCR2	CCR5	Yes	expression, binding	187	PF4, CCL16, P2RY14, CCL1, GRK1, CXCR1, GPR17, ADRA2B, AGT, HRH4, XCL1, CCL21, CCL4, P2RY4, GRM6, C3AR1, OPRM1, CCL19, SSTR5, HCAR2, CXCL12, NPB, FPR3, CXCL6, CCL25, CNR2, SAA1, CXCL14, NMUR1, GPR55, GRK4, CXCL1, GPER, OXGR1, GRM8, SSTR2, ADORA3, CCL22, CCL2, CCL28, NPY5R, CXCL3, PTGDR2, GAL, CCL23, TAS2R1, CCL11, S1PR4, JAK2, SSTR3, BDKRB2, NPY, ADRBK2, NMUR2, CCL7, CCL14, HRH3, OPRK1, P2RY13, HCAR3, CCL13, OPRL1, ADORA1, GPR18, TAS2R16, PNOC, HTR1E, ADRA2A, XCL2, CCR1, CCL20, NPBWR1, CXCL11, CCR6, CXCR2, GRK7, PENK, GNAT3, CCR9, CHRM2, PTGER3, ANXA1, MCHR1, P2RY12, PDYN, GNG2, CXCL13, DRD3, FPR2, SUCNR1, TAS2R42, CXCR6, MTNR1B, LPAR3, CXCR5, APP, TAS2R4, TAS2R41, RXFP3, TAS2R39, CXCL9, DRD2, POMC, CCL18, GALR2, NPY1R, PPBP, MCHR2, CXCR3, HTR5A, PPY, GRK5, CXCL2, CXCL16, HCAR1, CCR3, IL8, GRM3, HTR1F, CCR7, C5AR1, TAS2R5, HTR1A, TAS2R40, CX3CL1, CHRM4, TAS2R43, CXCL10, GNAI3, CCL8, OPRD1, BDKRB1, HTR1B, SST, APLNR, HEBP1, SSTR4, CCR10, KNG1, APLN, TAS2R60, RXFP4, LPAR5, PMCH, CCL4L1, CCR8, CXCR7, MTNR1A, GNAI1, CASR, S1PR1, CCL5, ARRB2, GRK6, CCL15-CCL14, ARRB1, ADRBK1, CCL3, S1PR5, GNB1, ADRA2C, LPAR2, CNR1, CXCL5, GALR1, OXER1, PF4V1, SSTR1, NMU, CCR4, GRM4, HTR1D, LPAR1, TAS2R3, PYY, S1PR3, GRM7, NMS, MTRNR2L2, GALR3, CCL17, CCL27, NPBWR2, GRM2, DRD4, NPY2R, NPW
CCR2	IFNG	No	-	3	IL2, JAK2, CXCL11
CCR2	IL10	No	-	6	IL2, CXCL10, IL8, ICAM1, CCL2, CCR5
CCR2	CXCL12	Yes	activation, binding	165	PF4, CCL16, P2RY14, P2RY12, GPR17, ADRA2B, AGT, HRH4, TAS2R4, ICAM1, GRM6, C3AR1, TAS2R16, CCL19, SSTR5, HCAR2, ANXA1, NPB, FPR3, CXCL6, CCL25, CNR2, SAA1, NMUR1, GPR55, CXCL1, GPER, OXGR1, GRM8, SSTR2, CCR5, ADORA3, TAS2R43, CCL28, NPY5R, CXCL3, PTGDR2, GAL, TAS2R1, CCL11, S1PR4, JAK2, SSTR3, APLN, KNG1, NMUR2, GALR1, CNR1, HRH3, OPRK1, P2RY13, HCAR3, OPRL1, ADORA1, GPR18, PNOC, HTR1E, ADRA2A, CXCR5, CCR1, CCL20, NPBWR1, CXCL11, CCR6, CXCR2, CXCL14, GNAT3, APLNR, CHRM2, PTGER3, MCHR1, CXCR1, PDYN, GNG2, CXCL13, DRD3, FPR2, SUCNR1, TAS2R42, CXCR6, MTNR1B, LPAR3, APP, PENK, TAS2R41, RXFP3, TAS2R39, CXCL9, DRD2, POMC, TAS2R3, CASR, GALR2, NPY1R, PPBP, MCHR2, CXCR3, HTR5A, PPY, S1PR5, CXCL2, CXCL16, CCR4, CCR3, IL8, GRM3, HTR1F, CCR7, C5AR1, TAS2R5, HTR1A, TAS2R40, CHRM4, CXCL10, GNAI3, OPRD1, BDKRB1, HTR1B, SST, CCR9, HEBP1, SSTR4, CCR10, BDKRB2, TAS2R60, LPAR5, PMCH, CCL27, CXCR7, MTNR1A, GNAI1, NPY, S1PR1, CCL5, ARRB2, GRK6, ARRB1, ADRBK1, GNB1, ADRA2C, LPAR2, CCL21, CXCL5, P2RY4, OXER1, SSTR1, NMU, HCAR1, GRM4, HTR1D, LPAR1, OPRM1, PYY, S1PR3, GRM7, NMS, MTRNR2L2, GALR3, RXFP4, CCR8, NPBWR2, GRM2, DRD4, NPY2R, NPW
CCR2	CCL3L1	No	-	3	CCR3, CCR5, CCR1
CCR5	IFNG	No	-	12	IL12RB2, STAT3, CXCL11, IL18R1, IL18RAP, IL18, TYK2, JUN, JAK2, IL12RB1, IL12A, ETV5
CCR5	IL10	Yes	activation, binding	11	IL12RB2, STAT3, ITIH4, CXCL10, IL4, IL12RB1, CCL2, JUN, CREB1, IL8, IL18
CCR5	CXCL12	Yes	activation, binding	181	PF4, CCL16, P2RY14, HGS, PLCG1, GPR17, ADRA2B, AGT, HRH4, GNAQ, TAS2R4, P2RY4, GRM6, C3AR1, TAS2R16, CCL19, SSTR5, GNAO1, ANXA1, NPB, FPR3, CXCL6, CCL25, CNR2, SAA1, ADRB2, GPR55, GNGT1, CXCL1, GPER, OXGR1, GRM8, SSTR2, ADORA3, CCR2, TAS2R43, CCL28, NPY5R, CXCL3, PTGDR2, GAL, TAS2R1, CCL11, TNFRSF1B, S1PR4, JAK2, PDYN, SSTR3, APLN, KNG1, NMUR2, GALR1, CNR1, HRH3, OPRK1, P2RY13, HCAR3, F2, GNAS, OPRL1, ADORA1, CHRM1, GPR18, PNOC, HTR1E, ADRA2A, CXCR5, CCR1, CCL20, S1PR3, NPBWR1, CXCL11, CXCR1, CXCR2, CXCL14, HCAR2, ADRA1B, GRM7, CHRM2, PTGER3, MCHR1, P2RY12, GRM4, GNG2, CXCL13, DRD3, FPR2, SUCNR1, DRD2, TAS2R42, CXCR6, MTNR1B, LPAR3, APP, PENK, TAS2R41, CCR9, RXFP3, TAS2R39, CCR6, CREB1, CXCL9, TAS2R3, CASR, GALR2, NPY1R, PPBP, MCHR2, CXCR3, HTR5A, PPY, S1PR5, CXCL2, STAT3, HCAR1, CCR3, IL8, GRM3, HTR1F, CCR7, C5AR1, EDN1, TAS2R5, HTR1A, TAS2R40, CHRM4, CXCL10, GNAI3, OPRD1, BDKRB1, HTR1B, SST, P2RY2, POMC, APLNR, HEBP1, SSTR4, CCR10, BDKRB2, TAS2R60, LPAR5, NMUR1, PMCH, CCR8, CXCR7, MTNR1A, GNAI1, NPY, S1PR1, CCL5, ARRB2, GNAT3, GRK6, ARRB1, ADRBK1, HRAS, GNB1, ADRA2C, LPAR2, CCL21, CXCL5, OXER1, SSTR1, NMU, CCR4, PTGER1, HTR1D, LPAR1, OPRM1, PYY, CXCL16, NMS, MTRNR2L2, GALR3, RXFP4, CCL27, NPBWR2, GRM2, DRD4, NPY2R, NPW
CCR5	CCL3L1	Yes	binding	2	CCR3, CCR1
IFNG	IL10	No	-	42	IL12RB2, CD80, OSMR, IL6R, IL20RB, IL12RB1, SOCS3, CTSB, STAT6, CNTFR, IL4R, IL23R, IL20RA, GHR, FOS, IL21R, IL2RB, IL3RA, IL22RA2, IL13RA1, EPOR, IL22RA1, IFNA2, PRLR, IFNAR1, CSF2RA, CRLF2, IL2, IFNAR2, JUN, MPL, IL5RA, IL6ST, IL28RA, STAT3, IL15RA, IFNGR2, IL18, JAK1, CSF2RB, IL9R, LIFR
IFNG	CXCL12	No	-	6	STAT3, CXCL11, MAPK1, PTPN11, JAK2, STAT5A
IL10	CXCL12	No	-	16	NOS3, CXCL10, EGR1, STAT3, CREB1, IL17A, MMP2, IL6, IL8, SMAD3, MMP9, HMOX1, VEGFA, SHH, ICAM1, CCR5
IL10	CCL3L1	No	-	1	CCR5
CXCL12	CCL3L1	No	-	3	CCR3, CCR5, CCR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
HLA-C	KIR3DL1	No	1	B2M

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Cytokine-cytokine receptor interaction	hsa04060	4.67	12	CX3CR1, CCL11, CCR2, IL10, CXCR1, IFNG, CCL3L1, CCL2, IL4R, CCL3, CXCL12, CCR5
Chemokine signaling pathway	hsa04062	5.19	9	CXCR1, CCL11, CCR2, CX3CR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
Chagas disease (American trypanosomiasis)	hsa05142	5.99	5	CCL3L1, CCL3, IL10, IFNG, CCL2
Rheumatoid arthritis	hsa05323	6.05	5	CCL3L1, CXCL12, CCL2, IFNG, CCL3
Herpes simplex infection	hsa05168	5.08	4	IFNG, TLR3, CCL2, HLA-C
Salmonella infection	hsa05132	6.29	3	CCL3, CCL3L1, IFNG
Antigen processing and presentation	hsa04612	6.04	3	KIR3DL1, HLA-C, IFNG
Natural killer cell mediated cytotoxicity	hsa04650	5.53	3	KIR3DL1, IFNG, HLA-C
Inflammatory bowel disease (IBD)	hsa05321	6.43	3	IL10, IFNG, IL4R
Toll-like receptor signaling pathway	hsa04620	6.0	3	CCL3, CCL3L1, TLR3
Allograft rejection	hsa05330	6.91	3	IL10, IFNG, HLA-C
Graft-versus-host disease	hsa05332	6.84	3	KIR3DL1, IFNG, HLA-C
Tuberculosis	hsa05152	5.17	3	CD209, IFNG, IL10
Endocytosis	hsa04144	4.92	3	CXCR1, CCR5, HLA-C
Malaria	hsa05144	7.15	3	IFNG, CCL2, IL10
Toxoplasmosis	hsa05145	5.71	3	CCR5, IFNG, IL10
Influenza A	hsa05164	5.21	3	TLR3, IFNG, CCL2
Jak-STAT signaling pathway	hsa04630	5.44	3	IL10, IFNG, IL4R
Epstein-Barr virus infection	hsa05169	4.97	3	IFNG, IL10, HLA-C
Amoebiasis	hsa05146	5.82	2	IL10, IFNG
African trypanosomiasis	hsa05143	7.68	2	IL10, IFNG
Systemic lupus erythematosus	hsa05322	5.95	2	IFNG, IL10
Autoimmune thyroid disease	hsa05320	6.62	2	IL10, HLA-C
Viral carcinogenesis	hsa05203	5.08	2	CCR5, HLA-C
T cell receptor signaling pathway	hsa04660	6.01	2	IFNG, IL10
Intestinal immune network for IgA production	hsa04672	6.79	2	CXCL12, IL10
Leishmaniasis	hsa05140	6.32	2	IL10, IFNG
Phagosome	hsa04145	5.27	2	CD209, HLA-C
Asthma	hsa05310	7.34	2	CCL11, IL10
Type I diabetes mellitus	hsa04940	6.79	2	HLA-C, IFNG
Measles	hsa05162	5.6	2	CD209, IFNG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Salmonella infection (hsa05132)	-	6.29	0.0	IFNG, IL10, CCR5, CCL3, CCL2, CCL3L3
Antigen processing and presentation (hsa04612)	-	6.04	0.001	KIR3DL1, IL10, CCR5, HLA-C, IFNG
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.008	KIR3DL1, IL10, CD209, IFNG, HLA-C
Allograft rejection (hsa05330)	-	6.91	0.035	IFNG, HLA-C, IL10
Jak-STAT signaling pathway (hsa04630)	-	5.44	0.009	IL4R, IL10, TLR3, IFNG, HLA-C
Intestinal immune network for IgA production (hsa04672)	-	6.79	0.004	CXCL12, CCR5, IL10, IFNG
Phagosome (hsa04145)	-	5.27	0.045	KIR3DL1, IFNG, CD209, HLA-C, IL10
Immune system	NEW	2.92	0.0	CCL3L3, CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
Asthma (hsa05310)	-	7.34	0.0	IL10, CCL11, IFNG, CCL2
NF-kappa B signaling pathway (hsa04064)	NEW	6.21	0.0	CXCR1, TLR3, CXCL12, IFNG, IL10, CCL2
Chemokine signaling pathway (hsa04062)	-	5.19	0.0	CCL3L3, CX3CR1, CCL11, CCR2, IL10, CXCR1, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
Cytokine-cytokine receptor interaction (hsa04060)	-	4.67	0.0	CCL3L3, CX3CR1, IFNG, CCL11, IL4R, TLR3, CCR2, CXCR1, CCL2, IL10, HLA-C, CCL3, CXCL12, CCR5
Chagas disease (American trypanosomiasis) (hsa05142)	-	5.99	0.0	IL10, IFNG, CCR5, CCL3, CCL2, CCL3L3
Herpes simplex infection (hsa05168)	-	5.08	0.011	TLR3, IFNG, IL10, HLA-C, CCL2, CCR5
Malaria (hsa05144)	-	7.15	0.005	IFNG, CCR5, CCL2, IL10
Influenza A (hsa05164)	-	5.21	0.009	TLR3, IFNG, IL10, CCL3, CCL2, CCR5
Measles (hsa05162)	-	5.6	0.012	TLR3, CD209, IFNG, IL10, IL4R
Immune diseases	NEW	4.47	0.0	CCL3L3, CCL11, HLA-C, TLR3, CXCL12, IL10, IFNG, CCL2, IL4R, KIR3DL1, CCL3, CCR5
Infectious diseases: Parasitic	NEW	4.46	0.003	TLR3, CCL3L3, IL10, IFNG, IL4R, CCL3, CCL2, CCR5
Infectious diseases: Bacterial	NEW	3.76	0.014	CXCR1, TLR3, CCL3L3, CD209, IFNG, CCL2, IL10, CCL3, CCR5
Rheumatoid arthritis (hsa05323)	-	6.05	0.0	CCL3L3, CXCL12, IFNG, IL10, CCL3, CCL2, CCR5
Infectious diseases: Viral	NEW	3.29	0.004	CXCR1, IFNG, IL4R, TLR3, CXCL12, CD209, IL10, CCL2, HLA-C, CCL3, CCR5
Inflammatory bowel disease (IBD) (hsa05321)	-	6.43	0.01	CCR5, IFNG, IL10, IL4R
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.0	TLR3, CCL3L3, IFNG, IL10, CCL3, CCL2, CCR5
RIG-I-like receptor signaling pathway (hsa04622)	NEW	6.62	0.005	CCL3, TLR3, IL10, IFNG
Signaling molecules and interaction	NEW	3.09	0.0	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IL10, CCL2, IL4R, CCL3, CXCL12, CCR5
TNF signaling pathway (hsa04668)	NEW	5.96	0.004	IL10, CCR5, TLR3, IFNG, CCL2
Graft-versus-host disease (hsa05332)	-	6.84	0.001	KIR3DL1, IL10, HLA-C, IFNG
Human Diseases	NEW	1.54	0.001	CCL3L3, CXCR1, CCL11, HLA-C, TLR3, CXCL12, CD209, IFNG, IL10, CCL2, IL4R, KIR3DL1, CCL3, CCR5
Organismal Systems	NEW	1.33	0.001	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
Environmental Information Processing	NEW	1.71	0.009	CCL3L3, CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, IL10, CCL2, IL4R, CCL3, CXCL12, CCR5
Staphylococcus aureus infection (hsa05150)	NEW	6.64	0.008	CXCR1, CCR5, IFNG, IL10

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signaling by GPCR	R-HSA-372790	2.68	9	CX3CR1, CCL11, CCR2, CXCR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69	9	CXCR1, CCL11, CCR2, CX3CR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
Peptide ligand-binding receptors	R-HSA-375276	5.41	9	CX3CR1, CCL11, CCR2, CXCR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
Chemokine receptors bind chemokines	R-HSA-380108	7.2	9	CXCR1, CCL11, CCR2, CX3CR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
GPCR ligand binding	R-HSA-500792	4.19	9	CXCR1, CCL11, CCR2, CX3CR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
Signal Transduction	R-HSA-162582	1.78	9	CXCR1, CCL11, CCR2, CX3CR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
Immune System	R-HSA-168256	2.37	6	TLR3, CCR2, CD209, IFNG, HLA-C, KIR3DL1
G alpha (i) signalling events	R-HSA-418594	5.1	4	CXCL12, CCR2, CXCR1, CCR5
Innate Immune System	R-HSA-168249	3.17	4	CCR2, CD209, TLR3, HLA-C
GPCR downstream signaling	R-HSA-388396	3.07	4	CXCR1, CCR2, CXCL12, CCR5
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	HLA-C, IFNG
Interferon gamma signaling	R-HSA-877300	5.67	2	IFNG, HLA-C
Interferon Signaling	R-HSA-913531	4.95	2	HLA-C, IFNG
Adaptive Immune System	R-HSA-1280218	3.19	2	KIR3DL1, HLA-C
Disease	R-HSA-1643685	3.33	2	CCR5, TLR3
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	4.7	2	KIR3DL1, HLA-C

NET-GE enrichment

Term	New enriched term	IC	Genes
Immune System (R-HSA-168256)	-	2.37	CXCR1, HLA-C, TLR3, CCR2, CD209, IL10, CCL2, IL4R, KIR3DL1, IFNG, CXCL12, CCR5
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)	-	4.69	CCL3L3, CXCR1, CCL11, IFNG, CCR2, CX3CR1, IL10, CCL2, CCL3, CXCL12, CCR5
Antigen processing-Cross presentation (R-HSA-1236975)	NEW	5.88	IL10, CCR5, IFNG, HLA-C
ER-Phagosome pathway (R-HSA-1236974)	NEW	6.08	IL10, HLA-C
Peptide ligand-binding receptors (R-HSA-375276)	-	5.41	CCL3L3, CX3CR1, CCL11, CCR2, IL10, CXCR1, IFNG, CCL2, CCL3, CXCL12, CCR5
Cytokine Signaling in Immune system (R-HSA-1280215)	-	3.74	TLR3, CCR5, IL10, IFNG, HLA-C
Interferon Signaling (R-HSA-913531)	-	4.95	IFNG, IL10, HLA-C
Class I MHC mediated antigen processing & presentation (R-HSA-983169)	NEW	4.65	TLR3, CXCL12, IFNG, IL10, HLA-C, CCR5
Interferon gamma signaling (R-HSA-877300)	-	5.67	IFNG, HLA-C
Chemokine receptors bind chemokines (R-HSA-380108)	-	7.2	CCL3L3, CXCR1, CCL11, CCR2, CX3CR1, IFNG, CCL2, CCL3, CXCL12, CCR5
Interferon alpha/beta signaling (R-HSA-909733)	NEW	6.04	IFNG, IL10, HLA-C
GPCR ligand binding (R-HSA-500792)	-	4.19	CCL3L3, CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL2, CCL3, CXCL12, CCR5
Adaptive Immune System (R-HSA-1280218)	-	3.19	HLA-C, TLR3, CXCL12, CD209, IFNG, IL10, IL4R, KIR3DL1, CCR5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (R-HSA-198933)	-	4.7	KIR3DL1, CCR5, HLA-C, IFNG

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	15	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, CCL3L1, IFNG, IL4R, CCL3, CXCL12, CCR5
protein binding (GO:0005515)	0.46	15	CX3CR1, CCL11, IL4R, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, CCL3L1, IFNG, HLA-C, CCL3, CXCL12, CCR5
molecular transducer activity (GO:0060089)	2.32	9	CX3CR1, HLA-C, TLR3, CCR2, CD209, CXCR1, IL4R, KIR3DL1, CCR5
receptor activity (GO:0004872)	2.32	9	CX3CR1, IL4R, TLR3, CCR2, CD209, CXCR1, HLA-C, KIR3DL1, CCR5
cytokine receptor binding (GO:0005126)	4.14	8	CCL11, CCR2, IFNG, CCL3L1, CXCL12, IL10, CCL3, CCL2
signaling receptor activity (GO:0038023)	2.49	8	CXCR1, IL4R, TLR3, CCR2, CX3CR1, HLA-C, KIR3DL1, CCR5
transmembrane signaling receptor activity (GO:0004888)	2.57	8	CXCR1, IL4R, TLR3, CCR2, CX3CR1, HLA-C, KIR3DL1, CCR5
signal transducer activity (GO:0004871)	2.28	8	CXCR1, IL4R, TLR3, CCR2, CX3CR1, HLA-C, KIR3DL1, CCR5
receptor binding (GO:0005102)	2.43	8	CCL11, CCR2, IL10, CCL3L1, CXCL12, IFNG, CCL3, CCL2
transmembrane receptor activity (GO:0099600)	2.53	8	CXCR1, IL4R, TLR3, CCR2, CX3CR1, HLA-C, KIR3DL1, CCR5
cytokine activity (GO:0005125)	4.34	7	CCL11, CXCL12, IL10, CCL3L1, IFNG, CCL3, CCL2
G-protein coupled receptor binding (GO:0001664)	4.18	6	CCL11, CXCL12, CCL2, CCL3L1, CCL3, CCR2
chemokine receptor binding (GO:0042379)	5.7	6	CCL11, CXCL12, CCL2, CCL3L1, CCL3, CCR2
chemokine activity (GO:0008009)	5.87	5	CCL3L1, CCL3, CCL11, CXCL12, CCL2
CCR chemokine receptor binding (GO:0048020)	6.21	5	CCR2, CCL11, CCL3L1, CCL2, CCL3
cytokine receptor activity (GO:0004896)	5.24	5	CX3CR1, CXCR1, CCR2, CCR5, IL4R
G-protein coupled peptide receptor activity (GO:0008528)	4.86	4	CX3CR1, CXCR1, CCR2, CCR5
G-protein coupled receptor activity (GO:0004930)	2.95	4	CXCR1, CCR2, CX3CR1, CCR5
G-protein coupled chemoattractant receptor activity (GO:0001637)	6.52	4	CX3CR1, CCR2, CXCR1, CCR5
chemokine binding (GO:0019956)	6.69	4	CX3CR1, CXCR1, CCR2, CCR5
cytokine binding (GO:0019955)	5.21	4	CX3CR1, CXCR1, CCR2, CCR5
chemokine receptor activity (GO:0004950)	6.52	4	CXCR1, CCR2, CX3CR1, CCR5
peptide receptor activity (GO:0001653)	4.84	4	CX3CR1, CXCR1, CCR2, CCR5
catalytic activity (GO:0003824)	1.05	3	CCL3, CCR5, CCL2
identical protein binding (GO:0042802)	2.63	3	CCL3, CCR2, TLR3
chemoattractant activity (GO:0042056)	6.48	2	CCL3, CXCL12
peptide binding (GO:0042277)	4.22	2	CD209, HLA-C
growth factor activity (GO:0008083)	4.66	2	CXCL12, IL10
peptide antigen binding (GO:0042605)	6.18	2	CD209, HLA-C
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	CCL3, CCL2
C-C chemokine binding (GO:0019957)	7.79	2	CCR2, CCR5
kinase activity (GO:0016301)	2.93	2	CCL3, CCL2
virus receptor activity (GO:0001618)	5.49	2	CD209, CCR5
transferase activity (GO:0016740)	1.95	2	CCL3, CCL2
protein kinase activity (GO:0004672)	3.27	2	CCL3, CCL2
antigen binding (GO:0003823)	5.02	2	CD209, HLA-C
amide binding (GO:0033218)	4.14	2	CD209, HLA-C
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	CCL3, CCL2
CCR2 chemokine receptor binding (GO:0031727)	8.64	2	CCR2, CCL2
C-C chemokine receptor activity (GO:0016493)	7.25	2	CCR2, CCR5
chemokine (C-C motif) ligand 5 binding (GO:0071791)	8.64	2	CCR2, CCR5

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine receptor binding (GO:0005126)	-	4.14	0.0	CCL3L3, CCL11, TLR3, CCR2, IL10, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
cytokine activity (GO:0005125)	-	4.34	0.0	CCL3L3, CCL11, TLR3, CXCL12, IFNG, IL10, HLA-C, CCL3, CCL2, CCR5
C-X-C chemokine binding (GO:0019958)	NEW	7.79	0.016	CXCR1, IFNG
chemokine activity (GO:0008009)	-	5.87	0.0	CCL3L3, CCL11, CXCL12, IFNG, IL10, CCL3, CCL2, CCR5
chemokine binding (GO:0019956)	-	6.69	0.001	CXCR1, CCR5, IFNG
cytokine binding (GO:0019955)	-	5.21	0.005	CXCR1, CCR5, IL10, IFNG, CCL2
chemokine receptor activity (GO:0004950)	-	6.52	0.0	CXCR1, CX3CR1, CCR2, CCR5, CCL2
calcium-dependent protein kinase C activity (GO:0004698)	NEW	8.35	0.006	CCL3, CCR5
G-protein coupled receptor binding (GO:0001664)	-	4.18	0.0	CCL3L3, CCL11, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
CCR chemokine receptor binding (GO:0048020)	-	6.21	0.006	CCL3, CCR2, CCL2
C-C chemokine receptor activity (GO:0016493)	-	7.25	0.015	CCR2, CCR5
G-protein coupled peptide receptor activity (GO:0008528)	-	4.86	0.007	CX3CR1, CXCR1, CCR5, CCR2, CCL2
chemokine receptor binding (GO:0042379)	-	5.7	0.0	CCL3L3, CCL11, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
peptide binding (GO:0042277)	-	4.22	0.0	CD209, CCR5, IFNG, IL10, HLA-C
peptide antigen binding (GO:0042605)	-	6.18	0.0	CD209, IL10, IFNG, HLA-C
cytokine receptor activity (GO:0004896)	-	5.24	0.0	CXCR1, CCR2, CX3CR1, IFNG, IL10, IL4R, CCL3, CCR5
amide binding (GO:0033218)	-	4.14	0.0	IL10, CCR5, CD209, IFNG, HLA-C
CCR2 chemokine receptor binding (GO:0031727)	-	8.64	0.001	CCR2, CCL2
peptide receptor activity (GO:0001653)	-	4.84	0.004	CX3CR1, CXCR1, CCR5, CCR2, CCL2
antigen binding (GO:0003823)	-	5.02	0.0	IFNG, CD209, TLR3, IL10, HLA-C
G-protein coupled chemoattractant receptor activity (GO:0001637)	-	6.52	0.0	CX3CR1, CXCR1, CCR5, CCR2, CCL2
calcium-dependent protein serine/threonine kinase activity (GO:0009931)	NEW	7.34	0.006	CCL3, CCR5

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
response to stimulus (GO:0050896)	1.22	16	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, IL10, CCL3L1, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
regulation of cellular process (GO:0050794)	0.5	16	CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IL10, CCL3L1, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
immune system process (GO:0002376)	2.29	16	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, CCL3L1, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
response to stress (GO:0006950)	1.8	16	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, CCL3L1, CXCL12, IL10, IL4R, KIR3DL1, CCL3, CCL2, CCR5
biological regulation (GO:0065007)	0.39	16	CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, CCL3L1, IL10, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
regulation of biological process (GO:0050789)	0.45	16	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, CCL3L1, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
defense response (GO:0006952)	2.78	15	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, CCL3L1, IL10, IL4R, KIR3DL1, CCL3, CCL2, CCR5
signal transduction (GO:0007165)	1.28	15	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, CCL3L1, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
single-organism process (GO:0044699)	0.48	15	CX3CR1, CCL11, TLR3, CCR2, CD209, CXCR1, IL10, CCL3L1, CXCL12, CCL2, IL4R, KIR3DL1, IFNG, CCL3, CCR5
cellular process (GO:0009987)	0.26	14	CX3CR1, CCL11, TLR3, CCR2, CD209, CXCR1, IFNG, IL10, CCL3L1, CCL2, HLA-C, CCL3, CXCL12, CCR5
regulation of response to stimulus (GO:0048583)	1.54	14	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CCL2, IL10, CCL3L1, IFNG, IL4R, KIR3DL1, CCL3, CXCL12
cell surface receptor signaling pathway (GO:0007166)	2.09	14	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, CCL3L1, CCL2, IL4R, CCL3, CXCL12, CCR5
immune response (GO:0006955)	2.86	14	CCL11, HLA-C, TLR3, CCR2, CD209, CCL2, IL10, CCL3L1, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
single-organism cellular process (GO:0044763)	0.65	13	CX3CR1, CCL11, IFNG, TLR3, CCR2, CD209, CXCR1, IL10, CCL3L1, CCL2, CCL3, CXCL12, CCR5
multi-organism process (GO:0051704)	2.65	13	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CCL2, IL10, IFNG, IL4R, CCL3, CXCL12, CCR5
positive regulation of biological process (GO:0048518)	1.2	12	CX3CR1, CCL11, TLR3, CCR2, CD209, IFNG, IL10, CCL3L1, CCL2, IL4R, CCL3, CXCL12
cytokine-mediated signaling pathway (GO:0019221)	3.6	12	CX3CR1, CCL11, HLA-C, CCR2, CXCR1, IFNG, CCL3L1, CCL2, IL4R, CCL3, CXCL12, CCR5
locomotion (GO:0040011)	2.91	11	CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL3L1, CCL2, CCL3, CXCL12, CCR5
cell migration (GO:0016477)	3.12	11	CX3CR1, CCL11, IFNG, CCR2, CXCR1, IL10, CCL3L1, CCL2, CCL3, CXCL12, CCR5
chemotaxis (GO:0006935)	4.04	11	CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL3L1, CCL2, CCL3, CXCL12, CCR5
taxis (GO:0042330)	4.03	11	CX3CR1, CCL11, IFNG, CCR2, CXCR1, IL10, CCL3L1, CCL2, CCL3, CXCL12, CCR5
cell motility (GO:0048870)	3.02	11	CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL3L1, CCL2, CCL3, CXCL12, CCR5
regulation of response to stress (GO:0080134)	2.53	11	CX3CR1, CCL11, TLR3, CCR2, CD209, IFNG, CCL3L1, CXCL12, IL10, CCL3, CCL2
positive regulation of response to stimulus (GO:0048584)	2.18	11	CCL11, TLR3, CCR2, CD209, IL10, CCL3L1, CXCL12, IFNG, IL4R, CCL3, CCL2
movement of cell or subcellular component (GO:0006928)	2.61	11	CX3CR1, CCL11, IFNG, CCR2, CXCR1, IL10, CCL3L1, CCL2, CCL3, CXCL12, CCR5
interspecies interaction between organisms (GO:0044419)	3.08	11	CX3CR1, CCL11, TLR3, CCR2, CD209, IFNG, CCL2, HLA-C, CCL3, CXCL12, CCR5
response to chemical (GO:0042221)	1.98	11	CX3CR1, CCL11, IFNG, TLR3, CCR2, IL10, CCL3L1, CCL2, CCL3, CXCL12, CCR5
regulation of immune system process (GO:0002682)	2.5	11	HLA-C, TLR3, CCR2, CD209, IFNG, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12
cell chemotaxis (GO:0060326)	4.63	11	CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL3L1, CCL2, CCL3, CXCL12, CCR5
negative regulation of biological process (GO:0048519)	1.33	11	CX3CR1, IFNG, TLR3, CCR2, IL10, CCL3L1, CCL2, IL4R, CCL3, CXCL12, CCR5
regulation of localization (GO:0032879)	1.94	11	CX3CR1, CCL11, TLR3, CCR2, IL10, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
response to organic substance (GO:0010033)	2.2	11	CX3CR1, CCL11, TLR3, CCR2, IFNG, CCL3L1, CXCL12, IL10, CCL3, CCL2, CCR5
negative regulation of cellular process (GO:0048523)	1.41	11	CX3CR1, IFNG, TLR3, CCR2, IL10, CCL3L1, CCL2, IL4R, CCL3, CXCL12, CCR5
positive regulation of cellular process (GO:0048522)	1.3	11	CX3CR1, CCL11, TLR3, CCR2, IL10, IFNG, CCL3L1, CCL2, IL4R, CCL3, CXCL12
regulation of cell proliferation (GO:0042127)	2.41	10	CX3CR1, CCL11, CCR2, CD209, IFNG, CCL3L1, CXCL12, IL10, IL4R, CCL2
viral process (GO:0016032)	3.15	10	CX3CR1, CCL11, TLR3, CCR2, CD209, CCL2, IFNG, HLA-C, CXCL12, CCR5
leukocyte chemotaxis (GO:0030595)	4.96	10	CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL3L1, CCL2, CCL3, CCR5
response to biotic stimulus (GO:0009607)	3.09	10	CX3CR1, CCL11, TLR3, CCR2, IL10, CCL2, IL4R, IFNG, CXCL12, CCR5
response to external stimulus (GO:0009605)	2.55	10	CX3CR1, CCL11, TLR3, CCR2, IL10, CCL2, IL4R, IFNG, CXCL12, CCR5
response to external biotic stimulus (GO:0043207)	3.13	10	CX3CR1, CCL11, TLR3, CCR2, IL10, CCL2, IL4R, IFNG, CXCL12, CCR5
regulation of developmental process (GO:0050793)	2.1	10	CX3CR1, CCL11, TLR3, CCR2, IL10, IFNG, CCL2, IL4R, CCL3, CXCL12
positive regulation of multicellular organismal process (GO:0051240)	2.49	10	CX3CR1, CCL11, IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3, CXCL12
leukocyte migration (GO:0050900)	4.19	10	CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL3L1, CCL2, CCL3, CCR5
multi-organism cellular process (GO:0044764)	3.14	10	CX3CR1, CCL11, TLR3, CCR2, CD209, IFNG, CCL2, HLA-C, CXCL12, CCR5
regulation of multicellular organismal development (GO:2000026)	2.31	10	CX3CR1, CCL11, TLR3, CCR2, IL10, IFNG, CCL2, IL4R, CCL3, CXCL12
regulation of multicellular organismal process (GO:0051239)	1.87	10	CX3CR1, CCL11, IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3, CXCL12
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	10	CX3CR1, CCL11, TLR3, CCR2, CD209, IFNG, CCL2, HLA-C, CXCL12, CCR5
regulation of biological quality (GO:0065008)	1.68	10	CX3CR1, CCL11, IFNG, CCR2, CD209, IL10, CCL2, CCL3, CXCL12, CCR5
regulation of defense response (GO:0031347)	3.11	10	CX3CR1, CCL11, IFNG, TLR3, CCR2, CD209, IL10, CCL3L1, CCL2, CCL3
cellular response to stimulus (GO:0051716)	1.97	9	CX3CR1, CCL11, IFNG, TLR3, IL10, CCL3L1, CCL2, CCL3, CCR5
inflammatory response (GO:0006954)	3.64	9	CXCR1, CCL11, TLR3, CCR2, IL10, CCL3L1, CCL2, CCL3, CCR5
regulation of response to external stimulus (GO:0032101)	3.06	9	CX3CR1, CCL11, TLR3, CCR2, IL10, CCL3L1, CCL2, CCL3, CXCL12
regulation of signal transduction (GO:0009966)	1.84	9	CX3CR1, CCL11, IFNG, TLR3, CXCL12, IL10, CCL3L1, CCL2, CCL3
chemokine-mediated signaling pathway (GO:0070098)	5.47	9	CX3CR1, CCL11, CCR2, CXCR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
cellular response to organic substance (GO:0071310)	2.78	9	CX3CR1, CCL11, IFNG, TLR3, IL10, CCL3L1, CCL2, CCL3, CCR5
cellular response to chemical stimulus (GO:0070887)	2.57	9	CX3CR1, CCL11, TLR3, IL10, CCL3L1, IFNG, CCL3, CCL2, CCR5
regulation of signaling (GO:0023051)	1.72	9	CX3CR1, CCL11, TLR3, CXCL12, IL10, CCL3L1, IFNG, CCL3, CCL2
regulation of cell communication (GO:0010646)	1.73	9	CX3CR1, CCL11, IFNG, TLR3, CXCL12, IL10, CCL3L1, CCL2, CCL3
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	9	CX3CR1, CCL11, CCR2, CXCR1, CCL2, CCL3L1, CCL3, CXCL12, CCR5
positive regulation of metabolic process (GO:0009893)	1.74	8	CCL11, TLR3, CCR2, IL10, CCL3L1, IFNG, CCL3, CCL2
regulation of metabolic process (GO:0019222)	1.02	8	CCL11, TLR3, CCR2, IFNG, CCL3L1, IL10, CCL3, CCL2
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	8	CX3CR1, CCL11, CCR2, IFNG, CCL2, IL4R, CCL3, CXCL12
regulation of transport (GO:0051049)	2.24	8	IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3, CXCL12
positive regulation of cellular metabolic process (GO:0031325)	1.81	8	CCL11, IFNG, TLR3, CCR2, IL10, CCL3L1, CCL2, CCL3
regulation of cellular metabolic process (GO:0031323)	1.07	8	CCL11, IFNG, TLR3, CCR2, IL10, CCL3L1, CCL2, CCL3
regulation of cell death (GO:0010941)	2.43	8	CX3CR1, TLR3, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2
regulation of apoptotic process (GO:0042981)	2.5	8	CX3CR1, IFNG, TLR3, CCR2, IL10, CCL2, CCL3, CXCL12
regulation of primary metabolic process (GO:0080090)	1.08	8	CCL11, TLR3, CCR2, IFNG, CCL3L1, IL10, CCL3, CCL2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	8	CCL11, TLR3, CCR2, IL10, CCL3L1, IFNG, CCL3, CCL2
negative regulation of multicellular organismal process (GO:0051241)	2.84	8	CX3CR1, IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3
regulation of protein metabolic process (GO:0051246)	1.93	8	CCL11, TLR3, CCR2, IL10, CCL3L1, IFNG, CCL3, CCL2
regulation of inflammatory response (GO:0050727)	4.03	8	CX3CR1, CCL11, TLR3, CCR2, IL10, CCL3L1, CCL2, CCL3
regulation of programmed cell death (GO:0043067)	2.49	8	CX3CR1, IFNG, TLR3, CCR2, IL10, CCL2, CCL3, CXCL12
regulation of molecular function (GO:0065009)	1.78	8	CCL11, TLR3, CCR2, IFNG, CCL3L1, IL10, CCL3, CCL2
positive regulation of transport (GO:0051050)	2.9	8	TLR3, CCR2, IL10, CXCL12, IFNG, IL4R, CCL3, CCL2
regulation of macromolecule metabolic process (GO:0060255)	1.08	8	CCL11, TLR3, CCR2, IFNG, CCL3L1, IL10, CCL3, CCL2
regulation of intracellular signal transduction (GO:1902531)	2.31	8	CCL11, TLR3, CXCL12, IL10, CCL3L1, IFNG, CCL3, CCL2
response to other organism (GO:0051707)	3.48	8	CCL11, TLR3, CCR2, IL10, CCL2, IL4R, IFNG, CXCL12
response to oxygen-containing compound (GO:1901700)	2.57	8	CX3CR1, CCR2, IFNG, CXCL12, IL10, CCL3, CCL2, CCR5
regulation of immune response (GO:0050776)	2.98	8	HLA-C, TLR3, CCR2, CD209, IFNG, IL10, IL4R, KIR3DL1
positive regulation of immune system process (GO:0002684)	2.96	8	TLR3, CCR2, CD209, IFNG, CCL2, IL4R, CCL3, CXCL12
regulation of phosphate metabolic process (GO:0019220)	2.35	7	CCL11, TLR3, CCR2, IFNG, CCL3L1, CCL2, CCL3
positive regulation of response to external stimulus (GO:0032103)	4.17	7	CCL11, TLR3, CCR2, CCL2, CCL3L1, CCL3, CXCL12
regulation of cell adhesion (GO:0030155)	3.27	7	CCR2, CD209, IL10, CXCL12, IFNG, IL4R, CCL2
regulation of cellular component organization (GO:0051128)	2.01	7	CCL11, CCR2, IFNG, CCL2, IL4R, CCL3, CXCL12
positive regulation of defense response (GO:0031349)	3.83	7	CCL11, TLR3, CCR2, CD209, CCL2, CCL3L1, CCL3
regulation of cell-cell adhesion (GO:0022407)	3.79	7	CCR2, CD209, IFNG, CXCL12, IL10, IL4R, CCL2
regulation of cell migration (GO:0030334)	3.23	7	CX3CR1, CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
positive regulation of cell communication (GO:0010647)	2.41	7	CCL11, TLR3, IFNG, CCL3L1, IL10, CCL3, CCL2
regulation of protein transport (GO:0051223)	3.12	7	TLR3, CCR2, IL10, IFNG, CCL2, IL4R, CCL3
intracellular signal transduction (GO:0035556)	2.39	7	CCL11, TLR3, CCR2, CD209, CCL2, CCL3, CCR5
regulation of protein localization (GO:0032880)	2.88	7	TLR3, CCR2, IL10, IFNG, IL4R, CCL3, CCL2
positive regulation of protein transport (GO:0051222)	3.61	7	IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3
positive regulation of establishment of protein localization (GO:1904951)	3.49	7	TLR3, CCR2, IL10, IFNG, IL4R, CCL3, CCL2
cellular macromolecule metabolic process (GO:0044260)	0.93	7	CXCR1, CCL11, TLR3, IL10, CCL2, CCL3, CCR5
positive regulation of signal transduction (GO:0009967)	2.5	7	CCL11, TLR3, IFNG, CCL3L1, IL10, CCL3, CCL2
positive regulation of protein metabolic process (GO:0051247)	2.43	7	CCL11, TLR3, CCR2, IFNG, CCL3L1, CCL2, CCL3
regulation of locomotion (GO:0040012)	3.12	7	CX3CR1, CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
organic substance metabolic process (GO:0071704)	0.63	7	CXCR1, CCL11, TLR3, IL10, CCL2, CCL3, CCR5
negative regulation of immune system process (GO:0002683)	3.85	7	TLR3, CCR2, IL10, CCL2, IL4R, CCL3, CXCL12
positive regulation of molecular function (GO:0044093)	2.23	7	CCL11, TLR3, IFNG, CCL3L1, IL10, CCL3, CCL2
negative regulation of response to stimulus (GO:0048585)	2.52	7	CX3CR1, TLR3, CCR2, IL10, CCL2, IL4R, CXCL12
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	7	CCR2, CD209, IL10, CXCL12, IFNG, IL4R, CCL2
regulation of establishment of protein localization (GO:0070201)	3.02	7	IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3
multicellular organismal process (GO:0032501)	1.45	7	CX3CR1, CCL11, CCR2, IFNG, IL10, IL4R, CXCL12
regulation of catalytic activity (GO:0050790)	1.97	7	CCL11, TLR3, CCR2, IFNG, CCL3L1, CCL2, CCL3
regulation of phosphorus metabolic process (GO:0051174)	2.35	7	CCL11, TLR3, CCR2, IFNG, CCL3L1, CCL2, CCL3
regulation of cell differentiation (GO:0045595)	2.42	7	CX3CR1, TLR3, CCR2, IFNG, IL4R, CCL3, CXCL12
regulation of cellular protein metabolic process (GO:0032268)	1.99	7	CCL11, TLR3, IFNG, CCL3L1, IL10, CCL3, CCL2
metabolic process (GO:0008152)	0.58	7	CXCR1, CCL11, TLR3, IL10, CCL2, CCL3, CCR5
positive regulation of intracellular signal transduction (GO:1902533)	2.95	7	CCL11, TLR3, IL10, CCL3L1, IFNG, CCL3, CCL2
negative regulation of developmental process (GO:0051093)	3.17	7	CX3CR1, TLR3, CCR2, IFNG, CCL2, IL4R, CCL3
positive regulation of signaling (GO:0023056)	2.41	7	CCL11, TLR3, IFNG, CCL3L1, IL10, CCL3, CCL2
regulation of cellular component movement (GO:0051270)	3.08	7	CX3CR1, CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
cellular metabolic process (GO:0044237)	0.69	7	CXCR1, CCL11, TLR3, IL10, CCL2, CCL3, CCR5
macromolecule metabolic process (GO:0043170)	0.83	7	CXCR1, CCL11, TLR3, IL10, CCL2, CCL3, CCR5
regulation of cytokine production (GO:0001817)	3.4	7	TLR3, CCR2, IL10, IFNG, IL4R, CCL3, CCL2
regulation of cell motility (GO:2000145)	3.16	7	CX3CR1, CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
response to lipid (GO:0033993)	3.11	7	CX3CR1, CCR2, IFNG, IL10, CCL3, CCL2, CCR5
positive regulation of cytokine production (GO:0001819)	3.82	7	TLR3, CCR2, IFNG, IL10, IL4R, CCL3, CCL2
cellular homeostasis (GO:0019725)	3.23	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
regulation of secretion (GO:0051046)	3.2	6	CCR2, IL10, IFNG, IL4R, CCL3, CXCL12
positive regulation of secretion (GO:0051047)	3.85	6	CCR2, IFNG, IL10, IL4R, CCL3, CXCL12
regulation of cell activation (GO:0050865)	3.53	6	CCR2, CD209, IL10, IFNG, IL4R, CCL2
ion homeostasis (GO:0050801)	3.42	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
regulation of T cell activation (GO:0050863)	4.05	6	CCR2, CD209, IFNG, IL10, IL4R, CCL2
homeostatic process (GO:0042592)	2.61	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
cell adhesion (GO:0007155)	2.82	6	CX3CR1, CCL11, CXCL12, CD209, IFNG, CCL2
regulation of secretion by cell (GO:1903530)	3.28	6	CCR2, IFNG, IL10, IL4R, CCL3, CXCL12
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)	5.1	6	TLR3, CCR2, IFNG, IL10, CCL3, CCL2
positive regulation of secretion by cell (GO:1903532)	3.93	6	CCR2, IFNG, IL10, IL4R, CCL3, CXCL12
inorganic ion homeostasis (GO:0098771)	3.43	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
response to lipopolysaccharide (GO:0032496)	4.03	6	CX3CR1, CCR2, IFNG, IL10, CCL2, CCR5
positive regulation of catalytic activity (GO:0043085)	2.4	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
divalent inorganic cation homeostasis (GO:0072507)	3.9	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
regulation of lymphocyte activation (GO:0051249)	3.73	6	CCR2, CD209, IL10, IFNG, IL4R, CCL2
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
regulation of leukocyte activation (GO:0002694)	3.6	6	CCR2, CD209, IFNG, IL10, IL4R, CCL2
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
regulation of protein modification process (GO:0031399)	2.32	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
biological adhesion (GO:0022610)	2.81	6	CX3CR1, CCL11, CXCL12, CD209, IFNG, CCL2
positive regulation of cell proliferation (GO:0008284)	3.01	6	CX3CR1, CCL11, CCR2, IFNG, CCL2, CXCL12
positive regulation of cell migration (GO:0030335)	3.77	6	CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
response to cytokine (GO:0034097)	3.84	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
positive regulation of phosphate metabolic process (GO:0045937)	2.78	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
cellular metal ion homeostasis (GO:0006875)	3.75	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
cellular calcium ion homeostasis (GO:0006874)	4.01	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
regulation of biosynthetic process (GO:0009889)	1.37	6	TLR3, CCR2, IFNG, IL10, CCL3, CCL2
cellular ion homeostasis (GO:0006873)	3.57	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
single-organism developmental process (GO:0044767)	1.49	6	CCL11, TLR3, CCR2, IL10, CCL2, CXCL12
positive regulation of inflammatory response (GO:0050729)	4.98	6	CCL11, TLR3, CCR2, CCL2, CCL3L1, CCL3
cellular cation homeostasis (GO:0030003)	3.6	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
metal ion homeostasis (GO:0055065)	3.61	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
cation homeostasis (GO:0055080)	3.46	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
cellular chemical homeostasis (GO:0055082)	3.4	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
localization (GO:0051179)	1.4	6	CXCR1, CD209, IFNG, IL10, CCL3, CCR5
regulation of phosphorylation (GO:0042325)	2.5	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
positive regulation of cellular component movement (GO:0051272)	3.71	6	CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
positive regulation of phosphorylation (GO:0042327)	2.9	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
positive regulation of locomotion (GO:0040017)	3.71	6	CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
single-multicellular organism process (GO:0044707)	1.78	6	CX3CR1, CCL11, CCR2, IL10, IL4R, CXCL12
positive regulation of developmental process (GO:0051094)	2.77	6	CX3CR1, CCL11, CCR2, IFNG, IL4R, CXCL12
cellular response to cytokine stimulus (GO:0071345)	4.33	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
positive regulation of protein modification process (GO:0031401)	2.7	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
chemical homeostasis (GO:0048878)	2.97	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
developmental process (GO:0032502)	1.36	6	CCL11, TLR3, CCR2, IL10, CCL2, CXCL12
regulation of tumor necrosis factor production (GO:0032680)	5.13	6	TLR3, CCR2, IFNG, IL10, CCL3, CCL2
regulation of immune effector process (GO:0002697)	3.71	6	TLR3, CCR2, IFNG, IL10, IL4R, CCL2
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	6	TLR3, CCR2, IFNG, IL10, CCL3, CCL2
response to molecule of bacterial origin (GO:0002237)	3.99	6	CX3CR1, CCR2, IFNG, IL10, CCL2, CCR5
positive regulation of cell motility (GO:2000147)	3.74	6	CCL11, CCR2, IFNG, CCL2, CCL3, CXCL12
immune effector process (GO:0002252)	3.58	6	CX3CR1, TLR3, IFNG, IL4R, KIR3DL1, CCL3
regulation of protein phosphorylation (GO:0001932)	2.57	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
myeloid leukocyte migration (GO:0097529)	5.13	6	CX3CR1, CCL11, IFNG, CCL3L1, CCL2, CCL3
positive regulation of protein phosphorylation (GO:0001934)	2.95	6	CCL11, TLR3, IFNG, CCL3L1, CCL2, CCL3
calcium ion homeostasis (GO:0055074)	3.97	6	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
regulation of cell morphogenesis (GO:0022604)	3.4	5	CCL3, CXCL12, CCL11, CCR2, CCL2
anatomical structure development (GO:0048856)	1.58	5	CXCL12, CCR2, TLR3, IL10, CCL2
cellular response to lipopolysaccharide (GO:0071222)	4.94	5	CX3CR1, CCR5, IL10, IFNG, CCL2
regulation of cellular localization (GO:0060341)	3.03	5	IFNG, IL10, TLR3, CCL2, IL4R
positive regulation of biosynthetic process (GO:0009891)	2.29	5	CCR2, IFNG, TLR3, IL10, CCL2
lymphocyte migration (GO:0072676)	5.86	5	CCL3L1, CCL3, CCL11, CCR2, CCL2
neutrophil migration (GO:1990266)	5.52	5	CCL3L1, CCL3, CCL11, CCL2, IFNG
positive regulation of tumor necrosis factor production (GO:0032760)	5.7	5	CCR2, TLR3, CCL2, IFNG, CCL3
regulation of cellular biosynthetic process (GO:0031326)	1.38	5	CCL3, IFNG, TLR3, CCR2, IL10
positive regulation of immune response (GO:0050778)	3.4	5	CCR2, CD209, TLR3, IFNG, IL4R
leukocyte activation (GO:0045321)	3.76	5	CX3CR1, CCL3, TLR3, IFNG, IL10
positive regulation of gene expression (GO:0010628)	2.35	5	CCL3, IFNG, TLR3, CCR2, IL10
regulation of leukocyte mediated immunity (GO:0002703)	4.7	5	CCR2, IFNG, TLR3, IL10, IL4R
positive regulation of cell death (GO:0010942)	3.32	5	CCL3, IFNG, TLR3, CCR2, IL10
lymphocyte chemotaxis (GO:0048247)	6.12	5	CCL3L1, CCL3, CCL11, CCR2, CCL2
response to organic cyclic compound (GO:0014070)	3.07	5	CCL3, CCR5, CCL2, IL10, TLR3
regulation of MAPK cascade (GO:0043408)	3.22	5	CCL3L1, CCL11, TLR3, CCL2, CCL3
cellular protein metabolic process (GO:0044267)	1.63	5	CCL3, CCR5, CCL11, TLR3, CCL2
single-organism metabolic process (GO:0044710)	1.63	5	CXCR1, CCL11, CCR5, CCL2, CCL3
regulation of protein secretion (GO:0050708)	3.77	5	CCR2, CCL3, IL10, IFNG, IL4R
positive regulation of hydrolase activity (GO:0051345)	2.91	5	CCL3L1, CCL11, IFNG, CCL2, CCL3
positive regulation of cell adhesion (GO:0045785)	3.79	5	CCR2, CXCL12, IFNG, CCL2, IL4R
regulation of cytokine secretion (GO:0050707)	4.74	5	CCL3, IFNG, CCR2, IL10, IL4R
positive regulation of MAPK cascade (GO:0043410)	3.57	5	CCL3, CCL11, CCL3L1, CCL2, TLR3
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	5	CCR2, IFNG, TLR3, CCL2, IL10
cellular component organization (GO:0016043)	1.24	5	CXCL12, CCL11, CCR5, CCL2, CCL3
positive regulation of apoptotic process (GO:0043065)	3.38	5	CCR2, TLR3, IL10, IFNG, CCL3
cellular component organization or biogenesis (GO:0071840)	1.22	5	CCL11, CCL3, CCR5, CXCL12, CCL2
granulocyte migration (GO:0097530)	5.41	5	CCL3L1, CCL11, IFNG, CCL2, CCL3
phosphorylation (GO:0016310)	2.63	5	CCL3, CCL11, CCR5, CCL2, TLR3
cellular response to biotic stimulus (GO:0071216)	4.76	5	IL10, CX3CR1, CCR5, CCL2, IFNG
granulocyte chemotaxis (GO:0071621)	5.48	5	CCL3L1, CCL3, CCL11, CCL2, IFNG
regulation of gene expression (GO:0010468)	1.37	5	CCR2, TLR3, IL10, IFNG, CCL3
positive regulation of cellular component organization (GO:0051130)	2.68	5	CXCL12, CCL11, IFNG, CCL2, IL4R
response to bacterium (GO:0009617)	4.18	5	CCR2, IL10, TLR3, IFNG, CCL2
protein phosphorylation (GO:0006468)	2.89	5	CCL3, CCL11, CCR5, CCL2, TLR3
neutrophil chemotaxis (GO:0030593)	5.59	5	CCL3L1, CCL11, IFNG, CCL2, CCL3
cellular response to molecule of bacterial origin (GO:0071219)	4.88	5	CX3CR1, CCR5, IL10, IFNG, CCL2
response to abiotic stimulus (GO:0009628)	2.8	5	CCR2, CCL11, CXCL12, CCL2, TLR3
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	5	CCL3, IL10, CCR2, IFNG, TLR3
transport (GO:0006810)	1.51	5	CD209, CCL3, CCR5, CXCR1, IFNG
cellular response to lipid (GO:0071396)	3.96	5	CX3CR1, CCR5, IL10, CCL2, IFNG
cellular protein modification process (GO:0006464)	1.79	5	CCL3, CCL11, CCR5, CCL2, TLR3
response to interferon-gamma (GO:0034341)	5.4	5	CCL3L1, CCL3, CCL11, TLR3, CCL2
positive regulation of cell differentiation (GO:0045597)	3.01	5	CX3CR1, CCR2, CXCL12, IFNG, IL4R
negative regulation of cell differentiation (GO:0045596)	3.33	5	CCR2, CCL3, TLR3, IFNG, IL4R
macromolecule modification (GO:0043412)	1.73	5	CCL3, CCR5, CCL11, TLR3, CCL2
protein modification process (GO:0036211)	1.79	5	CCL3, CCR5, CCL11, TLR3, CCL2
defense response to other organism (GO:0098542)	3.75	5	CCR2, IFNG, TLR3, IL10, IL4R
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	5	CCR2, IFNG, TLR3, IL10, CCL3
establishment of localization (GO:0051234)	1.48	5	CXCR1, CD209, CCR5, IFNG, CCL3
primary metabolic process (GO:0044238)	0.69	5	CCL3, CCL11, CCR5, CCL2, TLR3
regulation of hydrolase activity (GO:0051336)	2.53	5	CCL3L1, CCL11, IFNG, CCL2, CCL3
cellular response to oxygen-containing compound (GO:1901701)	3.22	5	CX3CR1, IFNG, CCR5, CCL2, IL10
positive regulation of cytokine secretion (GO:0050715)	5.16	5	CCR2, CCL3, IL10, IFNG, IL4R
positive regulation of protein secretion (GO:0050714)	4.39	5	CCR2, CCL3, IL10, IFNG, IL4R
protein metabolic process (GO:0019538)	1.45	5	CCL3, CCR5, CCL11, TLR3, CCL2
cellular response to interferon-gamma (GO:0071346)	5.78	5	CCL3, CCL11, CCL3L1, CCL2, TLR3
cell activation (GO:0001775)	3.47	5	CX3CR1, CCL3, TLR3, IFNG, IL10
positive regulation of programmed cell death (GO:0043068)	3.38	5	CCR2, TLR3, IL10, IFNG, CCL3
phosphate-containing compound metabolic process (GO:0006796)	2.16	5	CCL3, CCL11, CCR5, CCL2, TLR3
phosphorus metabolic process (GO:0006793)	2.15	5	CCL3, CCR5, CCL11, TLR3, CCL2
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	5.67	5	CCR2, IFNG, TLR3, CCL2, CCL3
regulation of intracellular transport (GO:0032386)	3.58	4	IL10, TLR3, CCL2, IL4R
regulation of chemotaxis (GO:0050920)	4.53	4	CCL3, CXCL12, CCR2, CCL2
positive regulation of chemotaxis (GO:0050921)	4.94	4	CCL3, CXCL12, CCR2, CCL2
regulation of production of molecular mediator of immune response (GO:0002700)	5.1	4	IFNG, TLR3, IL10, IL4R
regulation of cell killing (GO:0031341)	5.6	4	CCR2, IL10, CCL2, IFNG
signal transduction by protein phosphorylation (GO:0023014)	3.79	4	CCL3, CCL11, CCR5, CCL2
negative regulation of signal transduction (GO:0009968)	2.75	4	CX3CR1, CXCL12, TLR3, IL10
regulation of lymphocyte migration (GO:2000401)	6.12	4	CCL3, CXCL12, CCR2, CCL2
cellular developmental process (GO:0048869)	1.82	4	CCL3, IFNG, CCR2, IL10
cell activation involved in immune response (GO:0002263)	4.86	4	CX3CR1, TLR3, IFNG, CCL3
MAPK cascade (GO:0000165)	3.91	4	CCL3, CCL11, CCR5, CCL2
animal organ development (GO:0048513)	2.53	4	CXCL12, TLR3, CCL2, IL10
positive regulation of cell development (GO:0010720)	3.57	4	CX3CR1, CCR2, CXCL12, IFNG
regulation of interleukin-1 production (GO:0032652)	5.69	4	CCL3, IL10, CCR2, IFNG
negative regulation of cell death (GO:0060548)	2.95	4	CX3CR1, CXCL12, CCL2, IL10
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	4.99	4	CCR2, IL10, IFNG, IL4R
regulation of T cell proliferation (GO:0042129)	4.74	4	CCR2, CD209, IL10, IFNG
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	CCL3, TLR3, IFNG, IL10
regulation of hemopoiesis (GO:1903706)	4.0	4	CCL3, TLR3, IL4R, IFNG
single organism reproductive process (GO:0044702)	2.73	4	TLR3, IL10, CCL2, IL4R
regulation of cytokine biosynthetic process (GO:0042035)	5.15	4	CCR2, IFNG, TLR3, IL10
negative regulation of metabolic process (GO:0009892)	1.93	4	CCR2, IL10, IFNG, CCL3
response to virus (GO:0009615)	4.21	4	CXCL12, CCL11, TLR3, IFNG
negative regulation of biosynthetic process (GO:0009890)	2.47	4	CCR2, IL10, IFNG, CCL3
regulation of chemokine production (GO:0032642)	5.54	4	TLR3, IL10, IFNG, IL4R
regulation of lymphocyte proliferation (GO:0050670)	4.46	4	CCR2, CD209, IL10, IFNG
regulation of vasculature development (GO:1901342)	4.26	4	CCR2, CCL11, CX3CR1, CCL2
defense response to bacterium (GO:0042742)	4.31	4	CCR2, IL10, TLR3, IFNG
regulation of mononuclear cell proliferation (GO:0032944)	4.45	4	CCR2, CD209, IL10, IFNG
positive regulation of GTPase activity (GO:0043547)	3.28	4	CCL3L1, CCL11, CCL3, CCL2
cellular response to tumor necrosis factor (GO:0071356)	5.19	4	CCL3L1, CCL11, CCL3, CCL2
positive regulation of leukocyte migration (GO:0002687)	5.05	4	CCL3, CXCL12, CCR2, CCL2
regulation of leukocyte migration (GO:0002685)	4.72	4	CCL3, CXCL12, CCR2, CCL2
response to tumor necrosis factor (GO:0034612)	4.93	4	CCL3L1, CCL11, CCL3, CCL2
regulation of leukocyte chemotaxis (GO:0002688)	5.17	4	CCL3, CXCL12, CCR2, CCL2
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	3.82	4	CCL3, IFNG, CCR2, IL10
regulation of multi-organism process (GO:0043900)	3.6	4	CCL3, IL10, CCR2, IFNG
response to nitrogen compound (GO:1901698)	3.12	4	CXCL12, TLR3, CCL2, IL10
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	4	CCL3, CCL11, CCL3L1, CCL2
positive regulation of nervous system development (GO:0051962)	3.64	4	CX3CR1, CCR2, CXCL12, IFNG
positive regulation of leukocyte activation (GO:0002696)	4.0	4	CCR2, CCL2, IFNG, IL4R
positive regulation of leukocyte chemotaxis (GO:0002690)	5.35	4	CCL3, CXCL12, CCR2, CCL2
negative regulation of cell motility (GO:2000146)	4.36	4	CX3CR1, CCR2, CXCL12, CCL2
positive regulation of immune effector process (GO:0002699)	4.69	4	CCR2, CCL2, IFNG, IL4R
response to radiation (GO:0009314)	3.69	4	CCR2, CCL11, CXCL12, CCL2
cell differentiation (GO:0030154)	2.14	4	CCL3, IFNG, CCR2, IL10
regulation of adaptive immune response (GO:0002819)	4.91	4	CCR2, IFNG, IL10, IL4R
regulation of cellular protein localization (GO:1903827)	3.43	4	TLR3, IL10, CCL2, IFNG
negative regulation of signaling (GO:0023057)	2.65	4	CX3CR1, CXCL12, TLR3, IL10
negative regulation of cell communication (GO:0010648)	2.66	4	CX3CR1, CXCL12, TLR3, IL10
regulation of nervous system development (GO:0051960)	3.1	4	CX3CR1, CCR2, CXCL12, IFNG
regulation of GTPase activity (GO:0043087)	3.21	4	CCL3, CCL11, CCL3L1, CCL2
response to endogenous stimulus (GO:0009719)	2.79	4	CX3CR1, CXCL12, CCL2, IL10
regulation of neurogenesis (GO:0050767)	3.21	4	CX3CR1, CCR2, CXCL12, IFNG
regulation of cell development (GO:0060284)	3.01	4	CX3CR1, CCR2, CXCL12, IFNG
positive regulation of neurogenesis (GO:0050769)	3.77	4	CX3CR1, CCR2, CXCL12, IFNG
positive regulation of leukocyte cell-cell adhesion (GO:1903039)	4.35	4	CCR2, CCL2, IFNG, IL4R
regulation of interleukin-6 production (GO:0032675)	5.08	4	CCR2, IFNG, TLR3, IL10
negative regulation of cell proliferation (GO:0008285)	3.26	4	CCL3L1, CCR2, IL10, IFNG
negative regulation of cellular component movement (GO:0051271)	4.22	4	CX3CR1, CCR2, CXCL12, CCL2
positive regulation of T cell activation (GO:0050870)	4.39	4	CCR2, CCL2, IFNG, IL4R
regulation of vesicle-mediated transport (GO:0060627)	3.63	4	CCR2, CCL2, IFNG, IL4R
monocyte chemotaxis (GO:0002548)	6.04	4	CCL3L1, CCL11, CCL3, CCL2
regulation of epithelial cell proliferation (GO:0050678)	4.06	4	CXCL12, CCL11, CCL2, IFNG
positive regulation of lymphocyte activation (GO:0051251)	4.07	4	CCR2, IFNG, CCL2, IL4R
cellular response to organic cyclic compound (GO:0071407)	3.93	4	CCL3, TLR3, CCL2, IL10
regulation of RNA metabolic process (GO:0051252)	1.52	4	CCL3, TLR3, IFNG, IL10
response to drug (GO:0042493)	3.71	4	IFNG, TLR3, IL10, CCL2
leukocyte activation involved in immune response (GO:0002366)	4.88	4	CX3CR1, TLR3, IFNG, CCL3
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	4	CCL3L1, CCL11, CCL3, CCL2
cellular response to interleukin-1 (GO:0071347)	5.42	4	CCL3, CCL11, CCL3L1, CCL2
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	4	CCR2, IL10, TLR3, IFNG
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	4	CCL3, IFNG, CCR2, IL10
positive regulation of cell activation (GO:0050867)	3.97	4	CCR2, IFNG, CCL2, IL4R
negative regulation of cellular metabolic process (GO:0031324)	2.01	4	CCL3, IL10, CCR2, IFNG
positive regulation of cell-cell adhesion (GO:0022409)	4.23	4	CCR2, CCL2, IFNG, IL4R
response to interleukin-1 (GO:0070555)	5.07	4	CCL3, CCL11, CCL3L1, CCL2
regulation of angiogenesis (GO:0045765)	4.36	4	CCR2, CCL11, CX3CR1, CCL2
regulation of leukocyte proliferation (GO:0070663)	4.4	4	CCR2, CD209, IFNG, IL10
negative regulation of apoptotic process (GO:0043066)	3.04	4	CX3CR1, CXCL12, CCL2, IL10
negative regulation of programmed cell death (GO:0043069)	3.02	4	CX3CR1, CXCL12, IL10, CCL2
negative regulation of cell migration (GO:0030336)	4.41	4	CX3CR1, CCR2, CXCL12, CCL2
innate immune response (GO:0045087)	3.55	4	KIR3DL1, CD209, TLR3, HLA-C
reproductive process (GO:0022414)	2.55	4	IL4R, TLR3, IL10, CCL2
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	4	CCL3, IL10, CCR2, IFNG
establishment of localization in cell (GO:0051649)	2.47	4	CCL3, CD209, CCR5, IFNG
single-organism localization (GO:1902578)	2.09	4	CCL3, CCR5, CXCR1, IL10
negative regulation of locomotion (GO:0040013)	4.22	4	CX3CR1, CCR2, CXCL12, CCL2
regulation of leukocyte differentiation (GO:1902105)	4.26	4	CCL3, TLR3, IL4R, IFNG
regulation of growth (GO:0040008)	3.26	4	CCR2, CXCL12, IL10, IFNG
regulation of intracellular protein transport (GO:0033157)	3.8	3	TLR3, IL10, CCL2
positive regulation of intracellular transport (GO:0032388)	4.08	3	TLR3, CCL2, IL4R
positive regulation of alpha-beta T cell activation (GO:0046635)	5.76	3	CCR2, IL4R, IFNG
regulation of alpha-beta T cell activation (GO:0046634)	5.48	3	CCR2, IL4R, IFNG
behavior (GO:0007610)	3.47	3	CX3CR1, CCL3, CXCL12
regulation of homeostatic process (GO:0032844)	3.65	3	CCL3, CCR2, CCR5
negative regulation of cell adhesion (GO:0007162)	4.33	3	CXCL12, IL4R, IL10
positive regulation of cell killing (GO:0031343)	6.09	3	CCR2, IFNG, CCL2
interaction with host (GO:0051701)	4.86	3	CCR2, CD209, CCR5
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	CCL3, IL10, IFNG
response to wounding (GO:0009611)	4.39	3	CCR2, CX3CR1, CCL2
response to mechanical stimulus (GO:0009612)	4.41	3	CXCL12, TLR3, CCL2
negative regulation of hemopoiesis (GO:1903707)	4.96	3	CCL3, TLR3, IL4R
regulation of neuron differentiation (GO:0045664)	3.39	3	CCR2, CXCL12, IFNG
positive regulation of neuron differentiation (GO:0045666)	3.98	3	CCR2, CXCL12, IFNG
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817)	5.27	3	CCR2, CD209, CCL3
positive regulation of chemokine production (GO:0032722)	5.82	3	TLR3, IFNG, IL4R
regulation of interleukin-12 production (GO:0032655)	5.78	3	IFNG, TLR3, IL10
regulation of interleukin-1 beta production (GO:0032651)	5.88	3	CCL3, CCR2, IFNG
regulation of cell shape (GO:0008360)	4.77	3	CCL3, CCL11, CCL2
aging (GO:0007568)	4.16	3	CCR2, CCL2, IL10
response to peptide hormone (GO:0043434)	4.06	3	CXCL12, CCL2, IL10
regulation of calcium ion import (GO:0090279)	5.08	3	CCL3, CXCL12, CCL2
system process (GO:0003008)	2.3	3	CXCL12, CX3CR1, IFNG
single organism signaling (GO:0044700)	3.25	3	CCL3, CCR5, IL10
vesicle-mediated transport (GO:0016192)	2.72	3	CXCR1, CD209, CCL3
response to organonitrogen compound (GO:0010243)	3.2	3	CXCL12, CCL2, IL10
myeloid leukocyte activation (GO:0002274)	5.15	3	CCL3, CX3CR1, TLR3
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	3	CCL3, CCR2, CCR5
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	CCL3, IL10, IFNG
positive regulation of interleukin-1 beta production (GO:0032731)	6.33	3	CCL3, CCR2, IFNG
myeloid cell activation involved in immune response (GO:0002275)	6.07	3	CCL3, CX3CR1, TLR3
positive regulation of interleukin-1 production (GO:0032732)	6.15	3	CCL3, CCR2, IFNG
regulation of interferon-gamma production (GO:0032649)	5.21	3	CCR2, TLR3, IL10
negative regulation of vasculature development (GO:1901343)	5.32	3	CCR2, CX3CR1, CCL2
macrophage chemotaxis (GO:0048246)	7.16	3	CCL3, CX3CR1, CCL2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	CCL3, CCR2, IFNG
response to protozoan (GO:0001562)	6.73	3	IL10, IFNG, IL4R
immune response-regulating signaling pathway (GO:0002764)	3.72	3	CD209, TLR3, IFNG
regulation of interleukin-1 secretion (GO:0050704)	6.26	3	CCL3, CCR2, IFNG
regulation of interleukin-1 beta secretion (GO:0050706)	6.36	3	CCL3, CCR2, IFNG
positive regulation of lymphocyte migration (GO:2000403)	6.47	3	CCL3, CXCL12, CCR2
antigen processing and presentation (GO:0019882)	4.36	3	CD209, IFNG, HLA-C
negative regulation of multi-organism process (GO:0043901)	4.7	3	CCL3, IFNG, IL10
regulation of osteoclast differentiation (GO:0045670)	5.59	3	CCL3, TLR3, IFNG
T cell migration (GO:0072678)	7.09	3	CCL3, CCR2, CCL2
immune response-activating signal transduction (GO:0002757)	3.8	3	CD209, TLR3, IFNG
positive regulation of interleukin-1 secretion (GO:0050716)	6.55	3	CCL3, CCR2, IFNG
regulation of neurological system process (GO:0031644)	5.52	3	CCL3, IL10, IFNG
dendritic cell chemotaxis (GO:0002407)	6.96	3	CXCR1, CCR2, CCR5
negative regulation of leukocyte activation (GO:0002695)	4.79	3	CCR2, IL4R, IL10
regulation of transcription, DNA-templated (GO:0006355)	1.56	3	TLR3, IL10, IFNG
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	3	IFNG, TLR3, IL10
regulation of cellular extravasation (GO:0002691)	6.64	3	CCR2, CXCL12, CCL2
defense response to protozoan (GO:0042832)	6.84	3	IL10, IFNG, IL4R
response to alcohol (GO:0097305)	4.58	3	CCL3, CCR5, CCL2
regulation of myeloid cell differentiation (GO:0045637)	4.56	3	CCL3, TLR3, IFNG
negative regulation of response to external stimulus (GO:0032102)	4.18	3	CX3CR1, IL10, CCL2
modulation of synaptic transmission (GO:0050804)	4.09	3	CX3CR1, CCL2, IFNG
signaling (GO:0023052)	3.25	3	CCL3, CCR5, IL10
regulation of protein targeting (GO:1903533)	4.0	3	TLR3, IL10, CCL2
positive regulation of interleukin-1 beta secretion (GO:0050718)	6.59	3	CCL3, CCR2, IFNG
negative regulation of growth (GO:0045926)	4.24	3	CCR2, IFNG, IL10
anatomical structure morphogenesis (GO:0009653)	2.53	3	CCL11, IL10, CCL2
response to growth factor (GO:0070848)	4.14	3	CX3CR1, CCL2, IL10
positive regulation of cellular protein localization (GO:1903829)	3.85	3	TLR3, IFNG, CCL2
positive regulation of vasculature development (GO:1904018)	4.83	3	CCR2, CCL11, CX3CR1
positive regulation of calcium ion import (GO:0090280)	5.72	3	CCL3, CXCL12, CCL2
regulation of system process (GO:0044057)	3.53	3	CCL3, IFNG, IL10
negative regulation of leukocyte cell-cell adhesion (GO:1903038)	5.19	3	CXCL12, IL4R, IL10
regulation of exocytosis (GO:0017157)	4.59	3	CCR2, IL4R, IFNG
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	TLR3, IL10, IFNG
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	IFNG, TLR3, IL10
regulation of immunoglobulin production (GO:0002637)	5.86	3	IFNG, IL10, IL4R
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	TLR3, IL10, IFNG
negative regulation of immune response (GO:0050777)	4.94	3	CCR2, IL4R, IL10
dendritic cell migration (GO:0036336)	6.68	3	CXCR1, CCR2, CCR5
cellular response to growth factor stimulus (GO:0071363)	4.27	3	CX3CR1, IL10, CCL2
positive regulation of epithelial cell proliferation (GO:0050679)	4.67	3	CXCL12, CCL11, CCL2
response to hormone (GO:0009725)	3.33	3	CXCL12, IL10, CCL2
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	IFNG, TLR3, IL10
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	TLR3, IL10, IFNG
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	3	IFNG, TLR3, IL10
negative regulation of angiogenesis (GO:0016525)	5.42	3	CCR2, CX3CR1, CCL2
cellular defense response (GO:0006968)	5.65	3	CCR2, CX3CR1, CCR5
negative regulation of blood vessel morphogenesis (GO:2000181)	5.38	3	CCR2, CX3CR1, CCL2
negative regulation of cell activation (GO:0050866)	4.67	3	CCR2, IL4R, IL10
cell death (GO:0008219)	3.05	3	CCR2, TLR3, IFNG
negative regulation of cell-cell adhesion (GO:0022408)	4.84	3	CXCL12, IL4R, IL10
regulation of monocyte chemotaxis (GO:0090025)	6.73	3	CCR2, CXCL12, CCL2
positive regulation of monocyte chemotaxis (GO:0090026)	7.02	3	CCR2, CXCL12, CCL2
positive regulation of endothelial cell proliferation (GO:0001938)	5.51	3	CXCL12, CCL11, CCL2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	TLR3, IL10, IFNG
positive regulation of angiogenesis (GO:0045766)	4.93	3	CCR2, CCL11, CX3CR1
regulation of lymphocyte chemotaxis (GO:1901623)	6.78	3	CCL3, CCR2, CCL2
regulation of ion transport (GO:0043269)	3.4	3	CCL3, CXCL12, CCL2
regulation of myeloid leukocyte differentiation (GO:0002761)	5.02	3	CCL3, TLR3, IFNG
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	3	IFNG, TLR3, IL10
positive regulation of cytokine biosynthetic process (GO:0042108)	5.65	3	CCR2, TLR3, IFNG
regulation of metal ion transport (GO:0010959)	3.94	3	CCL3, CXCL12, CCL2
single-organism transport (GO:0044765)	2.18	3	CCL3, CXCR1, CCR5
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	3	IFNG, TLR3, IL10
cell-cell signaling (GO:0007267)	3.35	3	CCL3, CCR5, IL10
cell communication (GO:0007154)	3.04	3	CCL3, CCR5, IL10
organelle organization (GO:0006996)	2.02	3	CCL3, CCL11, CCL2
positive regulation of ion transport (GO:0043270)	4.36	3	CCL3, CXCL12, CCL2
cytoskeleton organization (GO:0007010)	3.22	3	CCL3, CCL11, CCL2
positive regulation of calcium ion transport (GO:0051928)	5.06	3	CCL3, CXCL12, CCL2
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	3	CCL3, CCR2, CCR5
regulation of innate immune response (GO:0045088)	3.86	3	CD209, TLR3, IFNG
regulation of calcium ion transport (GO:0051924)	4.38	3	CCL3, CXCL12, CCL2
negative regulation of immune effector process (GO:0002698)	5.1	3	CCR2, IL4R, IL10
negative regulation of leukocyte differentiation (GO:1902106)	5.3	3	CCL3, TLR3, IL4R
response to peptide (GO:1901652)	3.94	3	CXCL12, CCL2, IL10
adaptive immune response (GO:0002250)	4.43	3	CD209, IL4R, IFNG
activation of immune response (GO:0002253)	3.67	3	CD209, TLR3, IFNG
modification of morphology or physiology of other organism (GO:0035821)	5.12	3	CCL3, CD209, CCR2
positive regulation of interleukin-6 production (GO:0032755)	5.51	3	CCR2, TLR3, IFNG
regulation of endothelial cell proliferation (GO:0001936)	5.14	3	CXCL12, CCL11, CCL2
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	2	CXCL12, CX3CR1
regulation of membrane protein ectodomain proteolysis (GO:0051043)	6.68	2	IL10, IFNG
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	CXCL12, CX3CR1
negative regulation of secretion (GO:0051048)	4.44	2	CCR2, IL10
regulation of sequestering of calcium ion (GO:0051282)	5.07	2	CCL3, CCR5
negative regulation of sequestering of calcium ion (GO:0051283)	6.04	2	CCL3, CCR5
negative regulation of homeostatic process (GO:0032845)	4.91	2	CCL3, CCR5
regulation of actin polymerization or depolymerization (GO:0008064)	4.65	2	CXCL12, CCL11
regulation of lymphocyte mediated immunity (GO:0002706)	4.99	2	IL10, IFNG
positive regulation of leukocyte mediated immunity (GO:0002705)	5.32	2	IL4R, IFNG
regulation of neuron apoptotic process (GO:0043523)	4.47	2	CCL3, CCL2
positive regulation of production of molecular mediator of immune response (GO:0002702)	5.55	2	IL4R, IFNG
cellular localization (GO:0051641)	2.32	2	CD209, IFNG
regulation of axon extension (GO:0030516)	5.24	2	CCR2, CXCL12
negative regulation of myeloid cell differentiation (GO:0045638)	5.42	2	CCL3, TLR3
regulation of extent of cell growth (GO:0061387)	5.09	2	CCR2, CXCL12
regulation of cell projection organization (GO:0031344)	3.38	2	CCR2, CXCL12
negative regulation of inflammatory response (GO:0050728)	5.11	2	CX3CR1, IL10
response to cholesterol (GO:0070723)	6.68	2	CCL3, CCR5
positive regulation of killing of cells of other organism (GO:0051712)	7.78	2	CCR2, IFNG
regulation of tumor necrosis factor biosynthetic process (GO:0042534)	6.84	2	CCR2, IL10
positive regulation of alpha-beta T cell differentiation (GO:0046638)	6.12	2	IL4R, IFNG
regulation of cytoskeleton organization (GO:0051493)	3.72	2	CXCL12, CCL11
release of sequestered calcium ion into cytosol (GO:0051209)	6.04	2	CCL3, CCR5
regulation of alpha-beta T cell differentiation (GO:0046637)	5.9	2	IL4R, IFNG
negative regulation of molecular function (GO:0044092)	2.74	2	CCR2, IL10
modulation of growth of symbiont involved in interaction with host (GO:0044144)	6.9	2	IL10, IFNG
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	2	TLR3, IL10
STAT cascade (GO:0097696)	5.99	2	CCR2, CCL2
regulation of DNA metabolic process (GO:0051052)	3.87	2	IL10, IFNG
negative regulation of transport (GO:0051051)	3.6	2	CCR2, IL10
calcium-mediated signaling (GO:0019722)	5.24	2	CCL3, CCR5
response to corticosteroid (GO:0031960)	4.56	2	IL10, CCL2
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	5.48	2	CCR2, IFNG
regulation of T-helper 1 type immune response (GO:0002825)	6.64	2	CCR2, IL4R
positive regulation of adaptive immune response (GO:0002821)	5.42	2	CCR2, IFNG
developmental process involved in reproduction (GO:0003006)	3.36	2	TLR3, IL10
positive regulation of hemopoiesis (GO:1903708)	4.63	2	IL4R, IFNG
lymphocyte activation (GO:0046649)	3.96	2	IL10, IFNG
regulation of proteolysis (GO:0030162)	3.2	2	IL10, IFNG
calcium ion import into cytosol (GO:1902656)	5.99	2	CCL3, CCR5
regulation of neuron projection development (GO:0010975)	3.69	2	CCR2, CXCL12
divalent inorganic cation transport (GO:0072511)	4.13	2	CCL3, CCR5
negative regulation of chronic inflammatory response (GO:0002677)	7.94	2	CX3CR1, IL10
regulation of chronic inflammatory response (GO:0002676)	7.33	2	CX3CR1, IL10
regulation of transcription factor import into nucleus (GO:0042990)	5.16	2	TLR3, IL10
regulation of axonogenesis (GO:0050770)	4.59	2	CCR2, CXCL12
positive regulation of epithelial cell migration (GO:0010634)	5.09	2	CCR2, IFNG
regulation of protein import (GO:1904589)	4.52	2	TLR3, IL10
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	2	CD209, IFNG
response to activity (GO:0014823)	5.47	2	IL10, CCL2
endoplasmic reticulum unfolded protein response (GO:0030968)	5.07	2	CCL2, IFNG
regulation of epithelial cell migration (GO:0010632)	4.62	2	CCR2, IFNG
negative regulation of defense response (GO:0031348)	4.75	2	CX3CR1, IL10
single-organism behavior (GO:0044708)	3.79	2	CXCL12, CX3CR1
calcium ion transmembrane transport (GO:0070588)	4.67	2	CCL3, CCR5
positive regulation of T cell differentiation (GO:0045582)	5.52	2	IL4R, IFNG
regulation of nitric oxide biosynthetic process (GO:0045428)	5.76	2	IL10, IFNG
calcium ion import (GO:0070509)	5.57	2	CCL3, CCR5
cellular response to stress (GO:0033554)	2.51	2	CCL2, IFNG
lipopolysaccharide-mediated signaling pathway (GO:0031663)	6.26	2	CCL3, CCL2
positive regulation of interleukin-12 production (GO:0032735)	6.23	2	TLR3, IFNG
lymphocyte mediated immunity (GO:0002449)	5.59	2	KIR3DL1, IL4R
regulation of cellular component size (GO:0032535)	4.21	2	CXCL12, CCL11
regulation of interferon-alpha production (GO:0032647)	6.73	2	TLR3, IL10
regulation of isotype switching (GO:0045191)	6.55	2	IL10, IFNG
positive regulation of immune complex clearance by monocytes and macrophages (GO:0090265)	9.04	2	CCR2, CCL2
regulation of immune complex clearance by monocytes and macrophages (GO:0090264)	9.04	2	CCR2, CCL2
negative regulation of gene expression (GO:0010629)	2.48	2	CCL3, IFNG
morphogenesis of a branching structure (GO:0001763)	4.71	2	CCL11, IL10
positive regulation of mononuclear cell proliferation (GO:0032946)	4.84	2	CCR2, IFNG
second-messenger-mediated signaling (GO:0019932)	4.65	2	CCL3, CCR5
eosinophil chemotaxis (GO:0048245)	7.53	2	CCL3, CCL11
negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	6.96	2	IFNG, IL10
positive regulation of JAK-STAT cascade (GO:0046427)	5.44	2	IL10, IFNG
microglial cell activation involved in immune response (GO:0002282)	9.04	2	CX3CR1, TLR3
negative regulation of myeloid leukocyte differentiation (GO:0002762)	5.9	2	CCL3, TLR3
regulation of leukocyte degranulation (GO:0043300)	6.02	2	CCR2, IL4R
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	CD209, IFNG
regulation of JAK-STAT cascade (GO:0046425)	4.78	2	IL10, IFNG
telencephalon cell migration (GO:0022029)	5.99	2	CXCL12, CX3CR1
regulation of anatomical structure size (GO:0090066)	3.78	2	CXCL12, CCL11
negative regulation of leukocyte migration (GO:0002686)	6.29	2	CXCL12, CCL2
regulation of T cell migration (GO:2000404)	6.55	2	CCR2, CXCL12
inorganic cation transmembrane transport (GO:0098662)	3.55	2	CCL3, CCR5
positive regulation of T cell migration (GO:2000406)	6.68	2	CCR2, CXCL12
inorganic ion transmembrane transport (GO:0098660)	3.38	2	CCL3, CCR5
regulation of regulated secretory pathway (GO:1903305)	4.98	2	CCR2, IL4R
calcium ion transmembrane import into cytosol (GO:0097553)	5.99	2	CCL3, CCR5
single organism cell adhesion (GO:0098602)	3.63	2	CD209, IFNG
regulation of catabolic process (GO:0009894)	3.52	2	IL10, IFNG
cell-cell adhesion (GO:0098609)	3.34	2	CD209, IFNG
cation transport (GO:0006812)	3.11	2	CCL3, CCR5
ion transport (GO:0006811)	2.66	2	CCL3, CCR5
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0014808)	7.78	2	CCL3, CCR5
calcium ion transport (GO:0006816)	4.33	2	CCL3, CCR5
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	2	IFNG, IL10
positive regulation of multi-organism process (GO:0043902)	4.68	2	CCR2, IFNG
programmed cell death (GO:0012501)	3.1	2	TLR3, IFNG
eosinophil migration (GO:0072677)	7.43	2	CCL3, CCL11
response to temperature stimulus (GO:0009266)	4.71	2	CXCL12, CCL2
negative regulation of intracellular signal transduction (GO:1902532)	3.63	2	CXCL12, IL10
response to ionizing radiation (GO:0010212)	4.74	2	CCR2, CCL2
regulation of neuron death (GO:1901214)	4.19	2	CCL3, CCL2
regulation of growth of symbiont in host (GO:0044126)	6.96	2	IFNG, IL10
leukocyte differentiation (GO:0002521)	4.13	2	IL10, IFNG
response to hypoxia (GO:0001666)	4.13	2	CXCL12, CCL2
regulation of protein localization to nucleus (GO:1900180)	4.34	2	TLR3, IL10
endocytosis (GO:0006897)	3.69	2	CXCR1, CD209
defense response to virus (GO:0051607)	4.63	2	TLR3, IFNG
intracellular transport (GO:0046907)	2.67	2	CD209, IFNG
ion transmembrane transport (GO:0034220)	3.08	2	CCL3, CCR5
protein kinase B signaling (GO:0043491)	6.2	2	CCL3, CCL2
cellular response to nitrogen compound (GO:1901699)	3.79	2	TLR3, CCL2
innate immune response-activating signal transduction (GO:0002758)	4.45	2	CD209, TLR3
activation of innate immune response (GO:0002218)	4.41	2	CD209, TLR3
sarcoplasmic reticulum calcium ion transport (GO:0070296)	7.33	2	CCL3, CCR5
microglial cell activation (GO:0001774)	7.24	2	CX3CR1, TLR3
regulation of nucleocytoplasmic transport (GO:0046822)	4.33	2	TLR3, IL10
negative regulation of cytokine production (GO:0001818)	4.4	2	IL10, IFNG
positive regulation of cellular extravasation (GO:0002693)	7.24	2	CCR2, CCL2
modulation by virus of host morphology or physiology (GO:0019048)	6.12	2	CCR2, CD209
response to endoplasmic reticulum stress (GO:0034976)	4.46	2	CCL2, IFNG
regulation of developmental growth (GO:0048638)	4.04	2	CCR2, CXCL12
regulation of organelle organization (GO:0033043)	2.72	2	CXCL12, CCL11
astrocyte cell migration (GO:0043615)	7.94	2	CCL3, CCL2
regulation of actin cytoskeleton organization (GO:0032956)	4.09	2	CXCL12, CCL11
positive regulation of synaptic transmission (GO:0050806)	5.07	2	CCL2, IFNG
regulation of T cell differentiation (GO:0045580)	5.07	2	IL4R, IFNG
entry into host cell (GO:0030260)	5.3	2	CD209, CCR5
regulation of protein catabolic process (GO:0042176)	3.83	2	IL10, IFNG
response to glucocorticoid (GO:0051384)	4.63	2	CCL2, IL10
negative regulation of secretion by cell (GO:1903531)	4.55	2	CCR2, IL10
forebrain cell migration (GO:0021885)	5.92	2	CXCL12, CX3CR1
regulation of protein import into nucleus (GO:0042306)	4.54	2	TLR3, IL10
JAK-STAT cascade (GO:0007259)	5.99	2	CCR2, CCL2
humoral immune response (GO:0006959)	4.59	2	CCL2, IFNG
regulation of MHC class II biosynthetic process (GO:0045346)	7.16	2	IL10, IFNG
positive regulation of MHC class II biosynthetic process (GO:0045348)	7.65	2	IL10, IFNG
regeneration (GO:0031099)	4.7	2	CXCL12, CCL2
regulation of chemokine biosynthetic process (GO:0045073)	7.16	2	TLR3, IFNG
macrophage activation (GO:0042116)	6.29	2	CX3CR1, TLR3
regulation of cell morphogenesis involved in differentiation (GO:0010769)	3.91	2	CCR2, CXCL12
regulation of myeloid leukocyte mediated immunity (GO:0002886)	6.07	2	CCR2, IL4R
positive regulation of lymphocyte differentiation (GO:0045621)	5.35	2	IL4R, IFNG
response to decreased oxygen levels (GO:0036293)	4.09	2	CXCL12, CCL2
regulation of interleukin-8 production (GO:0032677)	5.62	2	TLR3, IL10
cellular response to endogenous stimulus (GO:0071495)	3.33	2	CX3CR1, CCL2
multicellular organismal reproductive process (GO:0048609)	3.35	2	IL4R, CCL2
viral genome replication (GO:0019079)	6.73	2	CD209, CCL2
neurological system process (GO:0050877)	2.64	2	CX3CR1, IFNG
positive regulation of interferon-gamma production (GO:0032729)	5.59	2	CCR2, TLR3
positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	6.43	2	IL4R, IFNG
regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)	6.09	2	IL4R, IFNG
regulation of cell growth (GO:0001558)	3.75	2	CCR2, CXCL12
metal ion transport (GO:0030001)	3.36	2	CCL3, CCR5
response to heat (GO:0009408)	5.24	2	CXCL12, CCL2
regulation of immunoglobulin mediated immune response (GO:0002889)	6.04	2	IFNG, IL10
transmembrane transport (GO:0055085)	2.72	2	CCL3, CCR5
positive regulation of immunoglobulin production (GO:0002639)	6.26	2	IL4R, IFNG
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	TLR3, IL10
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	TLR3, IL10
divalent metal ion transport (GO:0070838)	4.15	2	CCL3, CCR5
regulation of interferon-alpha biosynthetic process (GO:0045354)	7.94	2	TLR3, IL10
negative regulation of lymphocyte activation (GO:0051250)	4.95	2	IL4R, IL10
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	CCL3, IFNG
regulation of vascular endothelial growth factor production (GO:0010574)	6.29	2	CCR2, CCL2
positive regulation of lymphocyte proliferation (GO:0050671)	4.85	2	CCR2, IFNG
regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)	6.23	2	IL4R, IFNG
entry into other organism involved in symbiotic interaction (GO:0051828)	5.3	2	CD209, CCR5
regulation of lymphocyte differentiation (GO:0045619)	4.84	2	IL4R, IFNG
lymphocyte differentiation (GO:0030098)	4.49	2	IFNG, IL10
regulation of type I interferon production (GO:0032479)	5.03	2	TLR3, IL10
regulation of STAT cascade (GO:1904892)	4.78	2	IL10, IFNG
positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	6.55	2	IL4R, IFNG
response to steroid hormone (GO:0048545)	4.24	2	IL10, CCL2
positive regulation of STAT cascade (GO:1904894)	5.44	2	IFNG, IL10
regulation of cellular response to stress (GO:0080135)	3.4	2	CXCL12, TLR3
single organismal cell-cell adhesion (GO:0016337)	3.69	2	CD209, IFNG
negative regulation of T cell activation (GO:0050868)	5.26	2	IL4R, IL10
regulation of cellular catabolic process (GO:0031329)	3.83	2	IFNG, IL10
regulation of natural killer cell chemotaxis (GO:2000501)	7.65	2	CCL3, CCL2
regulation of B cell activation (GO:0050864)	4.92	2	IL10, IFNG
calcium ion transport from endoplasmic reticulum to cytosol (GO:1903514)	7.78	2	CCL3, CCR5
apoptotic signaling pathway (GO:0097190)	4.12	2	TLR3, IFNG
extrinsic apoptotic signaling pathway (GO:0097191)	5.16	2	TLR3, IFNG
cellular response to drug (GO:0035690)	5.48	2	TLR3, CCL2
response to insulin (GO:0032868)	4.72	2	IL10, CCL2
regulation of DNA recombination (GO:0000018)	5.65	2	IL10, IFNG
morphogenesis of an epithelium (GO:0002009)	4.08	2	CCL11, IL10
regulation of actin filament length (GO:0030832)	4.65	2	CXCL12, CCL11
regulation of type 2 immune response (GO:0002828)	6.47	2	CCR2, IL4R
regulation of sensory perception of pain (GO:0051930)	6.17	2	CCL3, IL10
regulation of sensory perception (GO:0051931)	6.17	2	CCL3, IL10
organ regeneration (GO:0031100)	5.3	2	CXCL12, CCL2
positive regulation of exocytosis (GO:0045921)	5.41	2	IL4R, IFNG
negative regulation of nervous system development (GO:0051961)	4.15	2	CCR2, IFNG
leukocyte mediated immunity (GO:0002443)	5.31	2	KIR3DL1, IL4R
regulation of ion homeostasis (GO:2000021)	4.44	2	CCL3, CCR5
positive regulation of leukocyte proliferation (GO:0070665)	4.79	2	CCR2, IFNG
negative regulation of growth of symbiont in host (GO:0044130)	7.02	2	IL10, IFNG
tissue morphogenesis (GO:0048729)	3.87	2	CCL11, IL10
organic substance transport (GO:0071702)	2.15	2	CD209, IFNG
regulation of reactive oxygen species biosynthetic process (GO:1903426)	5.55	2	IFNG, IL10
T cell chemotaxis (GO:0010818)	7.65	2	CCL3, CCR2
regulation of actin filament-based process (GO:0032970)	3.97	2	CXCL12, CCL11
positive regulation of innate immune response (GO:0045089)	4.22	2	CD209, TLR3
cytosolic calcium ion transport (GO:0060401)	5.74	2	CCL3, CCR5
calcium ion transport into cytosol (GO:0060402)	5.78	2	CCL3, CCR5
morphogenesis of a branching epithelium (GO:0061138)	4.77	2	CCL11, IL10
positive regulation of chemokine biosynthetic process (GO:0045080)	7.43	2	TLR3, IFNG
positive regulation of T cell proliferation (GO:0042102)	5.16	2	CCR2, IFNG
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	CCL3, IFNG
interferon-gamma-mediated signaling pathway (GO:0060333)	5.48	2	HLA-C, IFNG
regulation of B cell mediated immunity (GO:0002712)	6.02	2	IFNG, IL10
macrophage activation involved in immune response (GO:0002281)	7.33	2	CX3CR1, TLR3
leukocyte cell-cell adhesion (GO:0007159)	4.26	2	CD209, IFNG
regulation of cytokine production involved in immune response (GO:0002718)	5.69	2	TLR3, IL10
positive chemotaxis (GO:0050918)	6.17	2	CCL3, CXCL12
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	TLR3, CCL2
response to sterol (GO:0036314)	6.55	2	CCL3, CCR5
modification by symbiont of host morphology or physiology (GO:0044003)	5.92	2	CCR2, CD209
glial cell migration (GO:0008347)	6.68	2	CCL3, CCL2
response to oxygen levels (GO:0070482)	4.02	2	CXCL12, CCL2
receptor metabolic process (GO:0043112)	5.32	2	CXCR1, IL10
regulation of NF-kappaB import into nucleus (GO:0042345)	5.86	2	TLR3, IL10
regulation of neural precursor cell proliferation (GO:2000177)	5.45	2	CCR2, CX3CR1
regulation of leukocyte apoptotic process (GO:2000106)	5.33	2	CXCL12, IL10
regulation of killing of cells of other organism (GO:0051709)	7.65	2	CCR2, IFNG
positive regulation of leukocyte differentiation (GO:1902107)	4.85	2	IL4R, IFNG
entry into host (GO:0044409)	5.3	2	CD209, CCR5
negative regulation of osteoclast differentiation (GO:0045671)	6.51	2	CCL3, TLR3
entry into cell of other organism involved in symbiotic interaction (GO:0051806)	5.3	2	CD209, CCR5
cation transmembrane transport (GO:0098655)	3.43	2	CCL3, CCR5

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine-mediated signaling pathway (GO:0019221)	-	3.6	0.0	CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CXCR1, IL10, CCL2, IL4R, CCL3, CXCL12, CCR5
negative regulation of secretion (GO:0051048)	-	4.44	0.029	TLR3, CCR2, IL10, CCL2, HLA-C, CXCL12, CCR5
positive regulation of response to stimulus (GO:0048584)	-	2.18	0.0	TLR3, CCR2, IFNG, CCL2, HLA-C, CCL3, CXCL12
regulation of response to stimulus (GO:0048583)	-	1.54	0.0	CX3CR1, HLA-C, TLR3, CCR2, IL10, CCL2, IFNG, IL4R, KIR3DL1, CCL3, CXCL12
regulation of lymphocyte mediated immunity (GO:0002706)	-	4.99	0.0	KIR3DL1, IFNG, CCR5, HLA-C, IL10
positive regulation of leukocyte mediated immunity (GO:0002705)	-	5.32	0.0	KIR3DL1, IFNG, HLA-C, IL10
regulation of cytokine biosynthetic process (GO:0042035)	-	5.15	0.02	TLR3, CCR2, IFNG, IL10, HLA-C, CCR5
calcium ion homeostasis (GO:0055074)	-	3.97	0.004	CCL11, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
cell surface receptor signaling pathway (GO:0007166)	-	2.09	0.0	CX3CR1, HLA-C, TLR3, CCR2, CXCR1, CCL2, IFNG, IL4R, CCL3, CXCL12, CCR5
cell chemotaxis (GO:0060326)	-	4.63	0.0	CCL3L3, CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL2, CCL3, CXCL12, CCR5
positive regulation of transmembrane transport (GO:0034764)	NEW	4.99	0.029	CCL3, CCR5, CXCL12, CCL2
regulation of chemotaxis (GO:0050920)	-	4.53	0.04	CCL3, CXCL12, CCR2, CCL2
positive regulation of cell killing (GO:0031343)	-	6.09	0.0	KIR3DL1, IL10, IFNG, HLA-C
positive regulation of ion transmembrane transport (GO:0034767)	NEW	5.05	0.02	CCL3, CCR5, CXCL12, CCL2
regulation of T cell mediated immunity (GO:0002709)	NEW	5.76	0.0	IL10, IFNG, HLA-C
positive regulation of lymphocyte mediated immunity (GO:0002708)	NEW	5.49	0.0	KIR3DL1, IL10, IFNG, HLA-C
cellular response to stimulus (GO:0051716)	-	1.97	0.0	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
positive regulation of inflammatory response (GO:0050729)	-	4.98	0.003	TLR3, CCR2, IFNG, IL10, CCL3, CCR5
taxis (GO:0042330)	-	4.03	0.0	CCL3L3, CXCR1, CCL11, CCR2, CD209, CX3CR1, IFNG, CCL2, IL10, CCL3, CXCL12, CCR5
positive regulation of leukocyte migration (GO:0002687)	-	5.05	0.0	CCR2, IFNG, CXCL12, IL10, CCL3, CCL2, CCR5
regulation of tumor necrosis factor biosynthetic process (GO:0042534)	-	6.84	0.002	CCR2, CCR5, IL10, HLA-C
response to virus (GO:0009615)	-	4.21	0.002	CCL11, TLR3, CXCL12, IFNG, IL10, HLA-C, CCL3, CCL2, CCR5
cell activation involved in immune response (GO:0002263)	-	4.86	0.032	CX3CR1, TLR3, IFNG, IL10, CCL3, CCR5
MAPK cascade (GO:0000165)	-	3.91	0.015	CCL11, TLR3, IL10, CCL2, IL4R, CCL3, CCR5
regulation of leukocyte proliferation (GO:0070663)	-	4.4	0.05	TLR3, CCR2, CD209, IL10, CCL2, IFNG, CCR5
regulation of calcium ion import (GO:0090279)	-	5.08	0.011	CCL3, CXCL12, CCL2
interspecies interaction between organisms (GO:0044419)	-	3.08	0.0	CX3CR1, IFNG, HLA-C, TLR3, CCR2, CD209, IL10, CCL2, IL4R, CCL3, CCR5
regulation of leukocyte migration (GO:0002685)	-	4.72	0.028	CCL11, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817)	-	5.27	0.022	CD209, CCL3, CCR5, TLR3, IL10
positive regulation of biological process (GO:0048518)	-	1.2	0.0	CX3CR1, CCL11, HLA-C, TLR3, CCR2, IL10, CCL2, IFNG, IL4R, CCL3, CXCL12
biological regulation (GO:0065007)	-	0.39	0.001	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
negative regulation of immune system process (GO:0002683)	-	3.85	0.008	IL4R, TLR3, CCR2, IFNG, CXCL12, IL10, HLA-C, CCL2, CCR5
leukocyte chemotaxis (GO:0030595)	-	4.96	0.0	CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL2, CCL3, CXCL12, CCR5
regulation of interleukin-12 production (GO:0032655)	-	5.78	0.004	IL10, TLR3, CCR5, HLA-C, IFNG
neutrophil chemotaxis (GO:0030593)	-	5.59	0.043	CCL3, CCR5, IFNG, CCL2
chemotaxis (GO:0006935)	-	4.04	0.0	CCL3L3, CX3CR1, CCL11, IFNG, CCR2, CD209, CXCR1, IL10, CCL2, CCL3, CXCL12, CCR5
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	-	5.48	0.0	CCR2, IFNG, IL10, HLA-C
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	-	4.99	0.0	HLA-C, CCR2, IFNG, IL10, IL4R, CCR5
positive regulation of adaptive immune response (GO:0002821)	-	5.42	0.0	CCR2, IL10, HLA-C, IFNG
dendritic cell migration (GO:0036336)	-	6.68	0.005	CXCR1, CCR2, CCR5
response to other organism (GO:0051707)	-	3.48	0.045	CCL11, HLA-C, TLR3, CXCL12, IL10, CCL2, IFNG, IL4R, CCL3, CCR5
response to organic substance (GO:0010033)	-	2.2	0.0	CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CXCR1, IL10, CCL2, IL4R, CCL3, CXCL12, CCR5
multi-organism process (GO:0051704)	-	2.65	0.0	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, IFNG, IL10, CCL2, IL4R, CCL3, CXCL12, CCR5
regulation of regulated secretory pathway (GO:1903305)	-	4.98	0.004	CCR2, CXCL12, CCL2, IL10
response to biotic stimulus (GO:0009607)	-	3.09	0.0	CX3CR1, CCL11, TLR3, CXCL12, IL10, IFNG, CCL2, IL4R, CCL3, CCR5
response to external stimulus (GO:0009605)	-	2.55	0.0	CCL3L3, CX3CR1, CCL11, TLR3, CCR2, IL10, CXCR1, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
cell motility (GO:0048870)	-	3.02	0.0	CCL3L3, CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL2, CCL3, CXCL12, CCR5
lipopolysaccharide-mediated signaling pathway (GO:0031663)	-	6.26	0.002	CCL3, CCR5, CCL2, IL10
myeloid cell activation involved in immune response (GO:0002275)	-	6.07	0.017	CCL3, TLR3, CX3CR1, CCR5
myeloid leukocyte activation (GO:0002274)	-	5.15	0.007	CXCR1, TLR3, CX3CR1, IFNG, CCL3, CCR5
leukocyte migration (GO:0050900)	-	4.19	0.0	CXCR1, CCL11, IFNG, CCR2, CX3CR1, IL10, CCL2, CCL3, CXCL12, CCR5
immune system process (GO:0002376)	-	2.29	0.0	CCL3L3, CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	NEW	6.23	0.0	KIR3DL1, IFNG, HLA-C, IL10
regulation of leukocyte mediated cytotoxicity (GO:0001910)	NEW	5.78	0.0	KIR3DL1, IL10, IFNG, HLA-C
positive regulation of T cell mediated cytotoxicity (GO:0001916)	NEW	6.96	0.0	IFNG, IL10, HLA-C
regulation of T cell mediated cytotoxicity (GO:0001914)	NEW	6.59	0.0	IL10, HLA-C, IFNG
positive regulation of interleukin-12 production (GO:0032735)	-	6.23	0.007	IFNG, CCR5, TLR3, IL10
regulation of leukocyte mediated immunity (GO:0002703)	-	4.7	0.0	CCR2, IFNG, IL10, HLA-C, KIR3DL1, CXCL12, CCR5
positive regulation of chemotaxis (GO:0050921)	-	4.94	0.013	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
regulation of chemokine production (GO:0032642)	-	5.54	0.007	IFNG, CCR5, TLR3, CCL2, IL4R
regulation of interferon-gamma production (GO:0032649)	-	5.21	0.006	TLR3, CCR2, IFNG, IL10, HLA-C, CCR5
positive regulation of tumor necrosis factor production (GO:0032760)	-	5.7	0.032	CCL3, CCR5, IFNG, IL10, TLR3
positive regulation of immune complex clearance by monocytes and macrophages (GO:0090265)	-	9.04	0.005	CCR2, CCL2
regulation of immune complex clearance by monocytes and macrophages (GO:0090264)	-	9.04	0.005	CCR2, CCL2
regulation of cell killing (GO:0031341)	-	5.6	0.0	KIR3DL1, IFNG, HLA-C, IL10
regulation of mononuclear cell proliferation (GO:0032944)	-	4.45	0.044	TLR3, CCR2, CD209, IFNG, IL10, CCL2, CCR5
antigen processing and presentation of peptide antigen (GO:0048002)	NEW	4.56	0.0	IFNG, CCR5, HLA-C, IL10
eosinophil chemotaxis (GO:0048245)	-	7.53	0.015	CCL3, CCL11, CCL2
response to lipopolysaccharide (GO:0032496)	-	4.03	0.002	CX3CR1, IFNG, IL10, CCL3, CCL2, CCR5
lymphocyte chemotaxis (GO:0048247)	-	6.12	0.002	CCL3, CCR5, CCR2, IFNG, CCL2
regulation of biological process (GO:0050789)	-	0.45	0.0	CCL3L3, CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
regulation of myeloid leukocyte differentiation (GO:0002761)	-	5.02	0.027	TLR3, CXCL12, IFNG, HLA-C, CCL3, CCR5
regulation of leukocyte degranulation (GO:0043300)	-	6.02	0.004	CCR2, CXCL12, IL10, CCL2
cellular response to type I interferon (GO:0071357)	NEW	9.73	0.0	IFNG, IL10, HLA-C
regulation of cytokine secretion (GO:0050707)	-	4.74	0.0	CXCR1, HLA-C, TLR3, IFNG, IL10, IL4R, CCL3, CCR5
regulation of lymphocyte migration (GO:2000401)	-	6.12	0.001	CCL3, CXCL12, CCR5, CCR2, CCL2
positive regulation of immune system process (GO:0002684)	-	2.96	0.0	CCL11, HLA-C, TLR3, CCR2, IL10, IFNG, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
leukocyte activation involved in immune response (GO:0002366)	-	4.88	0.032	CX3CR1, TLR3, IFNG, IL10, CCL3, CCR5
regulation of immune system process (GO:0002682)	-	2.5	0.0	IFNG, HLA-C, TLR3, CCR2, CD209, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12
signal transduction by phosphorylation (GO:0023014)	-	3.79	0.047	CCL11, TLR3, IL10, CCL2, IL4R, CCL3, CCR5
cellular response to molecule of bacterial origin (GO:0071219)	-	4.88	0.0	CX3CR1, IL10, IFNG, CCL2, HLA-C, CCL3, CCR5
cellular response to biotic stimulus (GO:0071216)	-	4.76	0.002	CX3CR1, IFNG, IL10, CCL2, HLA-C, CCL3, CCR5
cell migration (GO:0016477)	-	3.12	0.0	CCL3L3, CXCR1, CCL11, CCR2, IL10, CX3CR1, IFNG, CCL2, CCL3, CXCL12, CCR5
regulation of leukocyte chemotaxis (GO:0002688)	-	5.17	0.002	CCR2, IL10, CCL2, CCL3, CXCL12, CCR5
antigen processing and presentation (GO:0019882)	-	4.36	0.0	TLR3, CD209, IFNG, IL10, HLA-C, CCR5
antigen processing and presentation of exogenous antigen (GO:0019884)	NEW	4.59	0.0	IFNG, CCR5, HLA-C, IL10
response to cytokine (GO:0034097)	-	3.84	0.0	CX3CR1, CCL11, HLA-C, TLR3, CCR2, IL10, CXCR1, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0014808)	-	7.78	0.043	CCL3, CCR5
regulation of cellular process (GO:0050794)	-	0.5	0.0	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
defense response (GO:0006952)	-	2.78	0.0	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, IL4R, KIR3DL1, CCL3, CCR5
response to stress (GO:0006950)	-	1.8	0.0	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
astrocyte cell migration (GO:0043615)	-	7.94	0.043	CCL3, CCL2
inflammatory response (GO:0006954)	-	3.64	0.0	CCL3L3, CXCR1, CCL11, IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3, CCR5
immune response (GO:0006955)	-	2.86	0.0	CCL3L3, CCL11, HLA-C, TLR3, CCR2, CD209, IFNG, CXCL12, IL10, IL4R, KIR3DL1, CCL2, CCR5
T cell migration (GO:0072678)	-	7.09	0.001	CCL3, CCR5, CCR2, CCL2
regulation of myeloid leukocyte mediated immunity (GO:0002886)	-	6.07	0.0	CCR2, CXCL12, IL10, IFNG, CCL2
cellular divalent inorganic cation homeostasis (GO:0072503)	-	3.96	0.017	CCL11, CCR2, IFNG, CXCL12, IL10, CCL3, CCL2, CCR5
positive regulation of T cell activation (GO:0050870)	-	4.39	0.006	CCL11, TLR3, CCR2, IL10, IFNG, IL4R, CCL2, CCR5
positive regulation of cytokine secretion (GO:0050715)	-	5.16	0.005	CXCR1, IFNG, IL10, IL4R, CCL3, CCR5
positive regulation of protein secretion (GO:0050714)	-	4.39	0.026	CCL3, IFNG, IL10, IL4R
cellular response to cytokine stimulus (GO:0071345)	-	4.33	0.0	CX3CR1, CCL11, HLA-C, TLR3, CCR2, IL10, CXCR1, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
response to stimulus (GO:0050896)	-	1.22	0.0	CCL3L3, CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, CCL2, IL10, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
cellular response to interferon-gamma (GO:0071346)	-	5.78	0.0	TLR3, IFNG, IL10, HLA-C, CCL3, CCL2
lymphocyte migration (GO:0072676)	-	5.86	0.0	CCL3, CCR5, CCR2, IFNG, CCL2
negative regulation of leukocyte activation (GO:0002695)	-	4.79	0.0	TLR3, CCR2, IFNG, CXCL12, IL10, IL4R, CCL2, CCR5
regulation of leukocyte activation (GO:0002694)	-	3.6	0.039	CXCR1, CCL11, TLR3, CCR2, CD209, IFNG, CXCL12, IL10, IL4R, CCL2, CCR5
regulation of immune effector process (GO:0002697)	-	3.71	0.0	HLA-C, TLR3, CCR2, IFNG, CXCL12, IL10, IL4R, KIR3DL1, CCL2, CCR5
negative regulation of multi-organism process (GO:0043901)	-	4.7	0.017	TLR3, IFNG, IL10, CCL3, CCL2, CCR5
regulation of cellular extravasation (GO:0002691)	-	6.64	0.013	CCR2, CXCL12, CCR5
positive regulation of leukocyte chemotaxis (GO:0002690)	-	5.35	0.002	CCR2, IL10, CCL2, CCL3, CXCL12, CCR5
response to external biotic stimulus (GO:0043207)	-	3.13	0.0	CX3CR1, CCL11, TLR3, CXCL12, IL10, IFNG, CCL2, IL4R, CCL3, CCR5
positive regulation of immune effector process (GO:0002699)	-	4.69	0.0	HLA-C, CCR2, IFNG, CXCL12, IL10, IL4R, KIR3DL1, CCL2, CCR5
negative regulation of immune effector process (GO:0002698)	-	5.1	0.0	HLA-C, TLR3, CCR2, IL10, IFNG, IL4R, CXCL12, CCR5
positive regulation of response to external stimulus (GO:0032103)	-	4.17	0.012	CCL11, TLR3, CCR2, IFNG, CXCL12, IL10, CCL3, CCL2, CCR5
eosinophil migration (GO:0072677)	-	7.43	0.017	CCL3, CCL11, CCL2
cell activation (GO:0001775)	-	3.47	0.029	CX3CR1, TLR3, CXCL12, IFNG, IL10, KIR3DL1, CCL3
response to temperature stimulus (GO:0009266)	-	4.71	0.006	CCL3L3, CXCL12, IFNG, IL10, HLA-C, CCL2, CCR5
chemokine-mediated signaling pathway (GO:0070098)	-	5.47	0.0	CX3CR1, CCR2, CXCR1, CCL2, CXCL12, CCR5
regulation of adaptive immune response (GO:0002819)	-	4.91	0.0	HLA-C, CCR2, IFNG, IL10, IL4R, CCR5
cellular defense response (GO:0006968)	-	5.65	0.001	CX3CR1, CCR2, IL10, IFNG, IL4R, CCR5
cellular response to chemical stimulus (GO:0070887)	-	2.57	0.0	CCL3L3, CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CXCR1, IL10, CCL2, IL4R, CCL3, CXCL12, CCR5
divalent inorganic cation homeostasis (GO:0072507)	-	3.9	0.029	CCL11, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
regulation of lymphocyte activation (GO:0051249)	-	3.73	0.02	CCR2, CD209, IL10, IFNG, IL4R, CCL2
positive regulation of calcium ion import (GO:0090280)	-	5.72	0.036	CCL3, CXCL12, CCL2
JAK-STAT cascade (GO:0007259)	-	5.99	0.024	CCR2, TLR3, IFNG, CCL2
regulation of cell activation (GO:0050865)	-	3.53	0.012	CXCR1, CCL11, TLR3, CCR2, CD209, IL10, CCL2, IL4R, IFNG, CXCL12, CCR5
granulocyte migration (GO:0097530)	-	5.41	0.002	CCL3, CCR5, CCL11, IFNG, CCL2
positive regulation of response to wounding (GO:1903036)	NEW	5.76	0.016	TLR3, CCR2, IFNG, IL10, CCL3, CCR5
neutrophil migration (GO:1990266)	-	5.52	0.046	CCL3, IFNG, CCL2
cellular metal ion homeostasis (GO:0006875)	-	3.75	0.023	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
cellular calcium ion homeostasis (GO:0006874)	-	4.01	0.014	CCL11, CCR2, IL10, CXCL12, IFNG, CCL3, CCL2, CCR5
cellular response to lipid (GO:0071396)	-	3.96	0.01	CX3CR1, IFNG, IL10, CCL3, CCL2, CCR5
cellular ion homeostasis (GO:0006873)	-	3.57	0.042	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
cellular cation homeostasis (GO:0030003)	-	3.6	0.035	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5
response to heat (GO:0009408)	-	5.24	0.0	CCL3L3, CXCR1, CXCL12, IL10, CCL2, HLA-C, CCR5
cellular component movement (GO:0006928)	-	2.61	0.003	CCL3L3, CXCR1, CCL11, IFNG, CCR2, CX3CR1, IL10, CCL2, CCL3, CXCL12, CCR5
negative regulation of immune response (GO:0050777)	-	4.94	0.004	TLR3, CCR2, IFNG, IL10, HLA-C, CCR5
regulation of immune response (GO:0050776)	-	2.98	0.0	HLA-C, TLR3, CCR2, CD209, IL10, CCL2, IL4R, KIR3DL1, IFNG, CXCL12, CCR5
regulation of interferon-alpha biosynthetic process (GO:0045354)	-	7.94	0.029	TLR3, IL10
leukocyte activation (GO:0045321)	-	3.76	0.002	CX3CR1, CCL11, TLR3, CXCL12, CXCR1, IFNG, IL10, HLA-C, KIR3DL1, CCL3, CCR5
regulation of lymphocyte proliferation (GO:0050670)	-	4.46	0.043	TLR3, CCR2, CD209, IL10, CCL2, IFNG, CCR5
positive regulation of immune response (GO:0050778)	-	3.4	0.0	TLR3, CCR2, IFNG, IL10, HLA-C, KIR3DL1, CCL2, CCR5
regulation of cytokine production (GO:0001817)	-	3.4	0.009	TLR3, CCR2, IL10, IFNG, IL4R, CCL3, CCL2
response to molecule of bacterial origin (GO:0002237)	-	3.99	0.002	CX3CR1, TLR3, IL10, IFNG, CCL2, HLA-C, CCL3, CCR5
macrophage chemotaxis (GO:0048246)	-	7.16	0.002	CX3CR1, CCL3, CCR5, CCL2
myeloid leukocyte migration (GO:0097529)	-	5.13	0.002	CX3CR1, CCL11, IFNG, CCL2, CCL3, CCR5
positive regulation of cytokine production (GO:0001819)	-	3.82	0.001	HLA-C, TLR3, CCR2, IL10, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
negative regulation of exocytosis (GO:0045920)	NEW	6.43	0.003	CCR2, CCR5, CXCL12, CCL2
dendritic cell chemotaxis (GO:0002407)	-	6.96	0.002	CCR2, CXCR1, CCR5
cellular response to lipopolysaccharide (GO:0071222)	-	4.94	0.0	CX3CR1, IFNG, IL10, CCL2, HLA-C, CCL3, CCR5
regulation of natural killer cell chemotaxis (GO:2000501)	-	7.65	0.043	CCL3, CCL2
negative regulation of cell activation (GO:0050866)	-	4.67	0.001	TLR3, CCR2, IFNG, CXCL12, IL10, IL4R, CCL2, CCR5
signal transduction (GO:0007165)	-	1.28	0.0	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
regulation of T cell activation (GO:0050863)	-	4.05	0.007	CCL11, TLR3, CCR2, CD209, IFNG, IL10, IL4R, CCL2, CCR5
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	NEW	5.54	0.0	IL10, CCR5, HLA-C, IFNG
positive regulation of protein transport (GO:0051222)	-	3.61	0.032	TLR3, CCL3, IFNG, IL10, IL4R
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	NEW	5.19	0.0	IL10, CCR5, IFNG, HLA-C
negative regulation of leukocyte differentiation (GO:1902106)	-	5.3	0.004	TLR3, IFNG, IL10, IL4R, CCL3, CCR5
positive regulation of lymphocyte migration (GO:2000403)	-	6.47	0.008	CCL3, CXCL12, CCR2, CCL2
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479)	NEW	5.59	0.0	CCR5, IFNG, IL10, HLA-C
antigen processing and presentation of exogenous peptide antigen (GO:0002478)	NEW	4.63	0.0	CCR5, IFNG, IL10, HLA-C
regulation of lymphocyte chemotaxis (GO:1901623)	-	6.78	0.002	CCL3, CCR2, CCL2
cellular response to organic substance (GO:0071310)	-	2.78	0.0	CX3CR1, IFNG, HLA-C, TLR3, CCR2, CXCR1, IL10, CCL2, IL4R, CCL3, CXCL12, CCR5
granulocyte chemotaxis (GO:0071621)	-	5.48	0.001	CCL11, CCL3, CCR5, CCL2, IFNG
T cell chemotaxis (GO:0010818)	-	7.65	0.001	CCL3, CCR2, CCR5
positive regulation of cytokine biosynthetic process (GO:0042108)	-	5.65	0.013	IL10, CCR2, CCR5, TLR3, IFNG
innate immune response (GO:0045087)	-	3.55	0.045	HLA-C, TLR3, CCR2, CD209, IL10, CCL2, IL4R, KIR3DL1, IFNG, CCR5
response to type I interferon (GO:0034340)	NEW	7.65	0.0	IL10, IFNG, HLA-C
response to interferon-gamma (GO:0034341)	-	5.4	0.0	TLR3, IFNG, IL10, HLA-C, CCL3, CCL2
positive regulation of T cell mediated immunity (GO:0002711)	NEW	6.23	0.0	IL10, IFNG, HLA-C
multi-organism cellular process (GO:0044764)	-	3.14	0.0	CX3CR1, CCR2, CD209, IFNG, IL10, HLA-C, CCL2, CCR5
type I interferon signaling pathway (GO:0060337)	NEW	5.59	0.0	IL10, HLA-C, IFNG
response to chemical (GO:0042221)	-	1.98	0.0	CCL3L3, CX3CR1, CCL11, HLA-C, TLR3, CCR2, IL10, CXCR1, IFNG, CCL2, IL4R, CCL3, CXCL12, CCR5
leukocyte mediated immunity (GO:0002443)	-	5.31	0.017	IFNG, TLR3, HLA-C, IL10, IL4R
locomotion (GO:0040011)	-	2.91	0.0	CCL3L3, CX3CR1, CCL11, IFNG, CCR2, CXCR1, IL10, CCL2, CCL3, CXCL12, CCR5
interferon-gamma-mediated signaling pathway (GO:0060333)	-	5.48	0.0	IFNG, HLA-C
regulation of myeloid cell differentiation (GO:0045637)	-	4.56	0.036	CXCR1, TLR3, CXCL12, IFNG, HLA-C, CCL3, CCR5
regulation of tumor necrosis factor production (GO:0032680)	-	5.13	0.0	IFNG, TLR3, CCR2, IL10, CCL2, HLA-C, CCL3, CCR5
regulation of leukocyte differentiation (GO:1902105)	-	4.26	0.03	HLA-C, TLR3, CXCL12, IL10, IFNG, IL4R, CCL3, CCR5
regulation of multicellular organismal development (GO:2000026)	-	2.31	0.028	CX3CR1, CCL11, IFNG, TLR3, CCR2, IL10, CCL2, IL4R, CCL3, CXCL12
viral process (GO:0016032)	-	3.15	0.0	CX3CR1, CCR2, CD209, IL10, CCL2, HLA-C, IFNG, CCR5
negative regulation of viral process (GO:0048525)	NEW	5.07	0.015	CCL3, CCR5, CCL2, IL10, TLR3
symbiosis, encompassing mutualism through parasitism (GO:0044403)	-	3.15	0.0	CX3CR1, CCR2, CD209, IL10, CCL2, HLA-C, IFNG, CCR5
positive regulation of behavior (GO:0048520)	NEW	6.47	0.027	CCL11, CCR2, CCL2, CCL3, CXCL12, CCR5

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	15	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
membrane part (GO:0044425)	0.95	11	CX3CR1, IL4R, TLR3, CCR2, CD209, CXCR1, IFNG, HLA-C, KIR3DL1, CXCL12, CCR5
membrane (GO:0016020)	0.68	10	CX3CR1, HLA-C, TLR3, CCR2, CD209, CXCR1, IL4R, KIR3DL1, CXCL12, CCR5
extracellular region part (GO:0044421)	1.57	10	CCL11, HLA-C, CXCL12, CD209, CCL2, IL10, CCL3L1, IFNG, IL4R, CCL3
extracellular region (GO:0005576)	2.18	10	CCL11, HLA-C, CXCL12, CD209, IFNG, IL10, CCL3L1, CCL2, IL4R, CCL3
intracellular part (GO:0044424)	0.28	9	CX3CR1, TLR3, CCR2, CD209, IL10, CCL2, HLA-C, CCL3, CCR5
integral component of membrane (GO:0016021)	1.14	9	CX3CR1, HLA-C, TLR3, CCR2, CD209, CXCR1, IL4R, KIR3DL1, CCR5
plasma membrane part (GO:0044459)	1.95	9	CX3CR1, HLA-C, TLR3, CCR2, IFNG, IL4R, KIR3DL1, CXCL12, CCR5
intrinsic component of membrane (GO:0031224)	1.13	9	CX3CR1, HLA-C, TLR3, CCR2, CD209, CXCR1, IL4R, KIR3DL1, CCR5
plasma membrane (GO:0005886)	1.39	9	CXCR1, IL4R, CCR2, CD209, CX3CR1, HLA-C, KIR3DL1, CXCL12, CCR5
extracellular space (GO:0005615)	2.63	8	CCL11, CXCL12, IL10, CCL3L1, IFNG, IL4R, CCL3, CCL2
cytoplasm (GO:0005737)	1.01	7	TLR3, CCR2, CD209, IL10, CCL2, CCL3, CCR5
membrane-bounded organelle (GO:0043227)	0.47	7	TLR3, CCR2, CD209, CCL2, HLA-C, CXCL12, CCR5
cytoplasmic part (GO:0044444)	0.82	7	CX3CR1, TLR3, CCR2, CCL2, HLA-C, CCL3, CCR5
integral component of plasma membrane (GO:0005887)	2.57	7	CX3CR1, IL4R, TLR3, CCR2, HLA-C, KIR3DL1, CCR5
intrinsic component of plasma membrane (GO:0031226)	2.53	7	CX3CR1, IL4R, TLR3, CCR2, HLA-C, KIR3DL1, CCR5
organelle (GO:0043226)	0.4	7	TLR3, CCR2, CD209, CCL2, HLA-C, CXCL12, CCR5
intracellular organelle (GO:0043229)	0.51	5	CCR2, CCR5, TLR3, CCL2, HLA-C
cell surface (GO:0009986)	3.44	5	CD209, CCR2, CCR5, TLR3, HLA-C
intracellular membrane-bounded organelle (GO:0043231)	0.6	5	CCR2, CCR5, CCL2, HLA-C, TLR3
intracellular (GO:0005622)	2.37	4	CCL3, CCL11, TLR3, IFNG
vesicle (GO:0031982)	1.64	4	CXCL12, CD209, HLA-C, CCL2
membrane-bounded vesicle (GO:0031988)	1.71	4	CXCL12, CD209, HLA-C, CCL2
external side of plasma membrane (GO:0009897)	4.46	3	CXCL12, CCR5, IFNG
extracellular vesicle (GO:1903561)	1.89	3	CXCL12, CD209, HLA-C
extracellular organelle (GO:0043230)	1.89	3	CXCL12, CD209, HLA-C
endoplasmic reticulum (GO:0005783)	2.56	3	TLR3, CCL2, HLA-C
vacuole (GO:0005773)	2.92	3	CCR2, CCR5, TLR3
neuron part (GO:0097458)	2.64	3	CCR2, CX3CR1, CCL2
neuron projection (GO:0043005)	3.12	3	CCR2, CX3CR1, CCL2
side of membrane (GO:0098552)	4.22	3	CXCL12, CCR5, IFNG
perinuclear region of cytoplasm (GO:0048471)	3.35	3	CCR2, CX3CR1, CCL2
cell projection (GO:0042995)	2.47	3	CCR2, CX3CR1, CCL2
endosome (GO:0005768)	3.25	3	CCR2, CCR5, TLR3
extracellular exosome (GO:0070062)	1.89	3	CXCL12, CD209, HLA-C
protein complex (GO:0043234)	1.51	2	IL4R, HLA-C
macromolecular complex (GO:0032991)	1.35	2	IL4R, HLA-C
perikaryon (GO:0043204)	5.13	2	CCR2, CCL2
bounding membrane of organelle (GO:0098588)	2.39	2	TLR3, HLA-C
cell body (GO:0044297)	3.74	2	CCR2, CCL2
dendrite (GO:0030425)	3.92	2	CCR2, CCL2
Golgi membrane (GO:0000139)	3.28	2	TLR3, HLA-C
intracellular organelle part (GO:0044446)	0.81	2	TLR3, HLA-C
endoplasmic reticulum part (GO:0044432)	2.73	2	TLR3, HLA-C
Golgi apparatus part (GO:0044431)	3.0	2	TLR3, HLA-C
vacuolar part (GO:0044437)	3.26	2	TLR3, HLA-C
organelle membrane (GO:0031090)	1.97	2	TLR3, HLA-C
endosomal part (GO:0044440)	3.73	2	TLR3, HLA-C
whole membrane (GO:0098805)	2.85	2	TLR3, HLA-C
vacuolar membrane (GO:0005774)	3.45	2	TLR3, HLA-C
neuronal cell body (GO:0043025)	3.9	2	CCR2, CCL2
cytosol (GO:0005829)	1.68	2	CCL3, CCR2
organelle part (GO:0044422)	0.79	2	TLR3, HLA-C
endosome membrane (GO:0010008)	3.83	2	TLR3, HLA-C

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
external side of plasma membrane (GO:0009897)	-	4.46	0.009	CXCL12, IFNG, IL10, HLA-C, CCL3, CCL2, CCR5
integral component of plasma membrane (GO:0005887)	-	2.57	0.0	CX3CR1, HLA-C, TLR3, CCR2, CD209, IFNG, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
Golgi apparatus (GO:0005794)	NEW	2.7	0.0	CD209, CCR5, IL10, IFNG, HLA-C
integral component of endoplasmic reticulum membrane (GO:0030176)	NEW	5.01	0.0	IFNG, IL10, HLA-C
integral component of organelle membrane (GO:0031301)	NEW	4.85	0.0	IFNG, IL10, HLA-C
side of membrane (GO:0098552)	-	4.22	0.039	CXCL12, IFNG, IL10, HLA-C, CCL3, CCL2, CCR5
endoplasmic reticulum (GO:0005783)	-	2.56	0.0	HLA-C, CCR5, TLR3, IFNG, CCL2
endocytic vesicle membrane (GO:0030666)	NEW	4.82	0.0	KIR3DL1, IL10, HLA-C, IFNG
extracellular space (GO:0005615)	-	2.63	0.017	CCL11, CXCL12, IL10, IFNG, IL4R, CCL3, CCL2, CCL3L3
coated vesicle membrane (GO:0030662)	NEW	5.0	0.0	IFNG, HLA-C, IL10
integral component of membrane (GO:0016021)	-	1.14	0.0	CX3CR1, HLA-C, TLR3, CCR2, CD209, CXCR1, IL4R, KIR3DL1, CCR5
membrane (GO:0016020)	-	0.68	0.012	CX3CR1, IFNG, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
Golgi apparatus part (GO:0044431)	-	3.0	0.0	TLR3, CXCL12, CD209, IFNG, IL10, HLA-C, CCR5
cytoplasmic vesicle part (GO:0044433)	NEW	3.41	0.0	KIR3DL1, IFNG, CCR5, IL10, HLA-C
endoplasmic reticulum part (GO:0044432)	-	2.73	0.0	TLR3, IFNG, IL10, HLA-C, CCL2, CCR5
integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556)	NEW	6.43	0.0	HLA-C, IFNG
endosome membrane (GO:0010008)	-	3.83	0.0	TLR3, IFNG, IL10, HLA-C, KIR3DL1, CCR5
plasma membrane part (GO:0044459)	-	1.95	0.0	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CCL2, IL10, IFNG, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
bounding membrane of organelle (GO:0098588)	-	2.39	0.0	TLR3, HLA-C
early endosome membrane (GO:0031901)	NEW	5.06	0.0	IFNG, HLA-C, IL10
MHC protein complex (GO:0042611)	NEW	6.43	0.0	IL10, IFNG, HLA-C
cell surface (GO:0009986)	-	3.44	0.0	TLR3, CD209, IFNG, IL10, HLA-C, CCL2, CCR5
transport vesicle membrane (GO:0030658)	NEW	4.86	0.0	IFNG, HLA-C, IL10
cytoplasmic vesicle membrane (GO:0030659)	NEW	3.67	0.0	KIR3DL1, IL10, CCR5, HLA-C, IFNG
vesicle membrane (GO:0012506)	NEW	3.63	0.0	KIR3DL1, IL10, CCR5, HLA-C, IFNG
plasma membrane (GO:0005886)	-	1.39	0.0	CX3CR1, CCL11, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, IL10, CCL2, IL4R, KIR3DL1, CCL3, CXCL12, CCR5
organelle membrane (GO:0031090)	-	1.97	0.0	TLR3, CXCL12, CD209, IL10, CCL2, HLA-C, KIR3DL1, IFNG, CCR5
protein complex (GO:0043234)	-	1.51	0.019	CCL11, HLA-C, TLR3, CCR2, IL10, CCL2, IL4R, IFNG, CXCL12, CCR5
macromolecular complex (GO:0032991)	-	1.35	0.004	CXCR1, CCL11, HLA-C, TLR3, CCR2, CCL2, IL10, IL4R, KIR3DL1, IFNG, CXCL12, CCR5
phagocytic vesicle membrane (GO:0030670)	NEW	5.71	0.0	KIR3DL1, IL10, HLA-C
membrane raft (GO:0045121)	NEW	4.18	0.007	CXCR1, CCL11, TLR3, IFNG, IL10, CCL2, CCR5
Golgi membrane (GO:0000139)	-	3.28	0.0	CD209, IL10, TLR3, IFNG, HLA-C
endosomal part (GO:0044440)	-	3.73	0.0	TLR3, IFNG, IL10, HLA-C, KIR3DL1, CCR5
membrane part (GO:0044425)	-	0.95	0.0	CX3CR1, HLA-C, TLR3, CCR2, CD209, CXCR1, IFNG, IL4R, KIR3DL1, CXCL12, CCR5