| Disease ID | Disease name | Source of annotation with FZD4 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS133780 | EXUDATIVE VITREORETINOPATHY | ClinVar, OMIM, HUMSAVAR | link to OMIM | 6 | NDP, TSPAN12, ZNF408, PRSS23, FZD4, LRP5 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 | 5.6 |
| Proteoglycans in cancer | hsa05205 | 5.02 |
| Pathways in cancer | hsa05200 | 3.98 |
| Basal cell carcinoma | hsa05217 | 6.79 |
| Melanogenesis | hsa04916 | 5.97 |
| Hippo signaling pathway | hsa04390 | 5.37 |
| HTLV-I infection | hsa05166 | 4.59 |
| Wnt signaling pathway | hsa04310 | 5.49 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 6.52 |
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 7.01 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| RNF mutants show enhanced WNT signaling and proliferation | R-HSA-5340588 | 9.98 |
| Diseases of signal transduction | R-HSA-5663202 | 4.89 |
| beta-catenin independent WNT signaling | R-HSA-3858494 | 5.83 |
| PCP/CE pathway | R-HSA-4086400 | 6.47 |
| Ca2+ pathway | R-HSA-4086398 | 7.1 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 9.08 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
| regulation of FZD by ubiquitination | R-HSA-4641263 | 8.59 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| Signaling by WNT in cancer | R-HSA-4791275 | 7.89 |
| Disease | R-HSA-1643685 | 3.33 |
| GO term | GO ID | GO IC |
|---|---|---|
| G-protein coupled receptor activity | GO:0004930 | 2.95 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| protein binding | GO:0005515 | 0.46 |
| protein heterodimerization activity | GO:0046982 | 3.64 |
| identical protein binding | GO:0042802 | 2.63 |
| cytokine binding | GO:0019955 | 5.21 |
| enzyme binding | GO:0019899 | 2.27 |
| Wnt-activated receptor activity | GO:0042813 | 6.65 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| PDZ domain binding | GO:0030165 | 5.22 |
| receptor activity | GO:0004872 | 2.32 |
| signal transducer activity | GO:0004871 | 2.28 |
| Wnt-protein binding | GO:0017147 | 6.3 |
| signaling receptor activity | GO:0038023 | 2.49 |
| protein dimerization activity | GO:0046983 | 2.72 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| protein domain specific binding | GO:0019904 | 3.32 |
| binding | GO:0005488 | 0.18 |