Gene table of DUSP6 : dual specificity phosphatase 6

Gene-disease associations table

Disease IDDisease nameSource of annotation with DUSP6OMIM linkNumber of associated genesgenes
PS147950HYPOGONADOTROPIC HYPOGONADISM WITH OR WITHOUT ANOSMIAClinVar, OMIM, HUMSAVAR link to OMIM 24TAC3, FGFR1, PROKR2, NSMF, WDR11, HS6ST1, TACR3, KISS1, FEZF1, KISS1R, DUSP6, SEMA3A, FGF17, ANOS1, FSHB, CHD7, FGF8, PROK2, FLRT3, GNRHR, IL17RD, SPRY4, GNRH1, LHB

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Annotation of the gene DUSP6

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Transcriptional misregulation in cancerhsa052025.21
MAPK signaling pathwayhsa040104.63
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
IRS-mediated signallingR-HSA-1123994.87
Nuclear Events (kinase and transcription factor activation)R-HSA-1987258.4
RAF-independent MAPK1/3 activationR-HSA-1124098.46
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Interleukin-2 signalingR-HSA-4519275.05
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
Signaling by EGFRR-HSA-1779294.59
MAP kinase activation in TLR cascadeR-HSA-4502947.28
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
ERK/MAPK targetsR-HSA-1987538.59
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
Downstream signal transductionR-HSA-1867634.65
RAF/MAP kinase cascadeR-HSA-56730015.15
MAPK targets/ Nuclear events mediated by MAP kinasesR-HSA-4502828.08
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Downstream signaling of activated FGFR3R-HSA-56547084.71
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
SHC1 events in ERBB4 signalingR-HSA-12503475.15
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
ERKs are inactivatedR-HSA-2026709.4
Axon guidanceR-HSA-4224753.93
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Signaling by LeptinR-HSA-25865525.1
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Toll-Like Receptors CascadesR-HSA-1688985.91
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Signalling to RASR-HSA-1670445.08
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
Signaling by FGFR1R-HSA-56547364.69
Signaling by PDGFR-HSA-1867974.53
Activated TLR4 signallingR-HSA-1660546.27
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Negative regulation of MAPK pathwayR-HSA-56752217.66
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
MAP kinase tyrosine/serine/threonine phosphatase activityGO:00170177.17
hydrolase activityGO:00167871.9
phosphatase activityGO:00167914.11
protein tyrosine/serine/threonine phosphatase activityGO:00081385.91
protein tyrosine phosphatase activityGO:00047255.09
phosphoprotein phosphatase activityGO:00047214.55
phosphoric ester hydrolase activityGO:00425783.82
catalytic activityGO:00038241.05
hydrolase activity, acting on ester bondsGO:00167883.1
MAP kinase phosphatase activityGO:00335497.1