| Disease ID | Disease name | Source of annotation with COMT | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 181500 | SCHIZOPHRENIA | OMIM | link to OMIM | 17 | COMT, DISC2, MTHFR, DISC1, CHI3L1, SYN2, MC4R, DAO, AKT1, HTR2A, APOL2, DTNBP1, SETD1A, DRD3, APOL4, RTN4R, DAOA |
| 167870 | PANIC DISORDER 1 | OMIM | link to OMIM | 1 | COMT |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Dopaminergic synapse | hsa04728 | 5.69 |
| Metabolic pathways | hsa01100 | 2.49 |
| Tyrosine metabolism | hsa00350 | 7.64 |
| Steroid hormone biosynthesis | hsa00140 | 6.93 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Enzymatic degradation of Dopamine by monoamine oxidase | R-HSA-379398 | 11.98 |
| Biological oxidations | R-HSA-211859 | 5.55 |
| Enzymatic degradation of dopamine by COMT | R-HSA-379397 | 11.98 |
| Methylation | R-HSA-156581 | 9.66 |
| Phase II conjugation | R-HSA-156580 | 6.52 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Dopamine clearance from the synaptic cleft | R-HSA-379401 | 11.4 |
| Neuronal System | R-HSA-112316 | 4.82 |
| Transmission across Chemical Synapses | R-HSA-112315 | 5.28 |
| Neurotransmitter Clearance In The Synaptic Cleft | R-HSA-112311 | 9.98 |
| GO term | GO ID | GO IC |
|---|---|---|
| cation binding | GO:0043169 | 1.4 |
| O-methyltransferase activity | GO:0008171 | 6.85 |
| S-adenosylmethionine-dependent methyltransferase activity | GO:0008757 | 4.81 |
| magnesium ion binding | GO:0000287 | 4.41 |
| ion binding | GO:0043167 | 1.36 |
| catalytic activity | GO:0003824 | 1.05 |
| transferase activity | GO:0016740 | 1.95 |
| transferase activity, transferring one-carbon groups | GO:0016741 | 4.3 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| methyltransferase activity | GO:0008168 | 4.35 |
| metal ion binding | GO:0046872 | 1.41 |
| catechol O-methyltransferase activity | GO:0016206 | 9.05 |